Design and process study of chiral separation of (2S,4S)-1-(tert-butoxy carbonyl)-4-(methoxymethyl) pyrrolidine-2-carboxylic acid for green manufacturing

Abstract

An effective approach to separate chiral ((2S, 4S)-1-(tert-butoxy carbonyl)-4-(methoxymethyl) pyrrolidine-2-carboxylic acid ((2S, 4S)-TBMP)) from mixed (2S, 4S)-TBMP and (2S, 4R)-1-(tert-butoxy carbonyl)-4-(methoxymethyl) pyrrolidine-2-carboxylic acid ((2S, 4R)-TBMP), an important intermediate for anti-HCV...