Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release

Meng, Yu-jie; Wang, Shuya; Guo, Zongwei; Cheng, Mei-mei; Li, Jun; Li, Deqiang

doi:10.1016/j.ijbiomac.2020.03.140

Cited by 41 publications

(6 citation statements)

References 44 publications

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“…The 5-FU release rates were well fitted with the Elovich model compared to other models. The Ritger–Peppas model and the first-order model were applied to drug release to describe the drug release process in the alkaline region [ 51 ]. This resulted in multiple drug release mechanisms: (1) the membrane surface of 5-FU released in the simulated environment, (2) the membrane layer breaking of the PEM induced drug release in the 5-FU, (3) the high concentration of the 5-FU in the inner layer drove drug release, (4) the polymer–solvent interactions, as well as the polymer–solute interactions, meant that the pectin-Ca +2 -based films displayed a higher drug release rate, i.e., 63.89%, in simulated intestinal fluid [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Polyelectrolyte Membranes of Pectin Graft-Copolymers with PVA and Their Composites with Phosphomolybdic Acid for Drug Delivery, Toxic Metal Ion Removal, and Fuel Cell Applications

et al. 2021

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In this study, a simple method for the fabrication of highly diffusive, adsorptive and conductive eco-friendly polyelectrolyte membranes (PEMs) with sulfonate functionalized pectin and poly(vinyl alcohol)(PVA) was established. The graft-copolymers were synthesized by employing the use of potassium persulfate as a free radical initiator from pectin (PC), a carbohydrate polymer with 2-acrylamido-2-methyl-1-propanesulphonic acid (AMPS) and sodium 4-vinylbenzene sulphonate (SVBS). The PEMs were fabricated from the blends of pectin graft-copolymers (PC-g-AMPS and PC-g-SVBS) and PVA by using a solution casting method, followed by chemical crosslinking with glutaraldehyde. The composite PEMs were fabricated by mixing phosphomolybdic acid with the aforementioned blends. The PEMs were successfully characterized by FTIR, XRD, SEM, and EDAX studies. They were assessed for the controlled release of an anti-cancer drug (5-fluorouracil) and the removal of toxic metal ions (Cu2+) from aqueous media. Furthermore, the composite PEMs were evaluated for fuel cell application. The 5-fluorouracil release capacity of the PEMs was found to be 93% and 99.1% at 300 min in a phosphate buffer solution (pH = 7.4). The highest Cu2+ removal was observed at 206.7 and 190.1 mg/g. The phosphomolybdic acid-embedded PEMs showed superior methanol permeability, i.e., 6.83 × 10−5, and 5.94 × 10−5, compared to the pristine PEMs. Furthermore, the same trend was observed for the proton conductivities, i.e., 13.77 × 10−3, and 18.6 × 10−3 S/cm at 30 °C.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Polyelectrolyte Membranes of Pectin Graft-Copolymers with PVA and Their Composites with Phosphomolybdic Acid for Drug Delivery, Toxic Metal Ion Removal, and Fuel Cell Applications

et al. 2021

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“…In principle, pectin consists of (1 → 4)-α-D-galacturonic acid (Gal A) residues with various neutral sugar branches. Pectin chains can be divided into “smooth regions,” which are linear anionic backbones without side chains, and “hairy regions,” which contain nonionic side chains (( Sriamornsak, 2003 , Meng et al, 2020 ). The structure of pectin is depicted in Fig.…”

Section: Pectin In Pharmaceutical Formulationsmentioning

confidence: 99%

“…The ability of pectin to form gels and interact with various substances is exploited in drug delivery systems, where it helps to control the release of medications over time. Furthermore, pectin has been used as a binder and disintegrant in pharmaceutical tablets to ensure proper drug absorption and effectiveness ( Meng et al, 2020 ).…”

Section: Pectin In Pharmaceutical Formulationsmentioning

confidence: 99%

Pectin hydrogels for controlled drug release: Recent developments and future prospects

Kapoor,

Garg,

Gaur

et al. 2024

Saudi Pharmaceutical Journal

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“…The functional groups contained in pectin were modified according to the method of Yu-Jie Meng et al [7].…”

Section: Pectin Characterizationmentioning

confidence: 99%

Extraction and Characterization of Pectin from Jerusalem ArtiChoke Residue and Its Application in Blueberry Preservation

Zhou

Liu

et al. 2022

Coatings

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To prolong the storage period of blueberry and improve its shelf-life quality, an edible coating based on chitosan was developed, and different contents of pectin were added to the coating. In this study, Jerusalem artichoke residue was used as a source of pectin, which is a byproduct of the processing of inulin. The extracted pectin has a low cost and high quality, which is very suitable for the preservation of coating. The coating was prepared and the chemical properties of the coating were characterized by SEM, XRD, TG, and FTIR. The barrier properties of the coating were analyzed by thickness, water content, solubility, and water vapor permeability. The results showed that the pectin coating exhibited excellent performance in blueberry preservation. Following 16 days of storage, the decay and weight loss rates of blueberry treated with 0.2% pectin coating decreased by 33 and 22%, respectively. Moreover, the organic acid consumption of the coated blueberry slowed and the anthocyanins were better preserved. As a low-cost, safe, and efficient technology, the pectin chitosan composite coating has significant potential in the berries preservation industry.

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Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release

Cited by 41 publications

References 44 publications

Fabrication of Polyelectrolyte Membranes of Pectin Graft-Copolymers with PVA and Their Composites with Phosphomolybdic Acid for Drug Delivery, Toxic Metal Ion Removal, and Fuel Cell Applications

Fabrication of Polyelectrolyte Membranes of Pectin Graft-Copolymers with PVA and Their Composites with Phosphomolybdic Acid for Drug Delivery, Toxic Metal Ion Removal, and Fuel Cell Applications

Pectin hydrogels for controlled drug release: Recent developments and future prospects

Extraction and Characterization of Pectin from Jerusalem ArtiChoke Residue and Its Application in Blueberry Preservation

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