Design and other methodological considerations for the construction of human fetal and neonatal size and growth charts

Ohuma, Eric O; Altman, Douglas G.

doi:10.1002/sim.8000

Cited by 33 publications

(33 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first two special issue papers by Ohuma and Altman address the question of how to best construct age‐ and gender‐adjusted reference growth charts. Such charts are the basis through which parents might learn from the paediatrician that their child is, for example, in the 95% for length (or height for older children) and 90% for weight.…”

mentioning

confidence: 99%

“…As illustration, they use data from the INTERGROWTH‐21 project, which also includes prenatal head circumference data. The second paper by Ohuma and Altman draws from their experience with the INTERGROWTH‐21 study to offer design guidelines. The third and fourth papers in the special issue address the question of how to model repeated standardised growth measures in a longitudinal setting .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Four papers on child growth modelling

Ryan

2019

Statistics in Medicine

View full text Add to dashboard Cite

mentioning

confidence: 99%

mentioning

confidence: 99%

Four papers on child growth modelling

Ryan

2019

Statistics in Medicine

View full text Add to dashboard Cite

“…Professor Douglas Altman's involvement in the Intergrowth-21 st project motivated him to revisit the methodology and study design of growth references and standards (115). Along with Ohuma, the paper discusses many of the recommendations outlined in Altman's previous papers on this subject (97,98) but in more depth.…”

Section: Study Design For Reference Centile Creationmentioning

confidence: 99%

“…The authors criticise population specific reference intervals as being "fallacious" due to variations in fetal growth across regions being dictated by their geographical location and that these artificial boundaries nullify within population heterogeneity (114). However, both methodologies are valid but use different approaches to devise different reference charts (115).…”

Section: Study Design For Reference Centile Creationmentioning

confidence: 99%

“…The authors address the use of cross-sectional data for charts on fetal size and longitudinal data for charts on fetal growth (trajectories) and the choice of data depends on the use for which the charts are intended. They also emphasise the importance of appropriate populations and samples, and the subsequent ability to generalise to the general population for which the charts are intended (115). This point is expanded to discuss the descriptive verses prescriptive approaches to reference charts and the utility of both approaches.…”

Section: Study Design For Reference Centile Creationmentioning

confidence: 99%

See 1 more Smart Citation

Maternal and perinatal factors associated with adverse perinatal outcomes at term and the development of a predictive model for identification of at–risk pregnancies.

Flatley¹

View full text Add to dashboard Cite

The perinatal period is defined as being between 20 weeks gestation and up to 28 days after birth.Despite advancements in antenatal care, diagnostic tools, interventions and treatments, adverse perinatal outcomes such as stillbirth, fetal growth restriction, preterm birth, hypoxic ischaemic encephalopathy, serious neonatal morbidity and neonatal death still occur. Placental dysfunction is one of the major contributors to these adverse outcomes regardless of gestation. While the majority of fetuses are able to cope with the increase in metabolic requirements in the last few weeks of pregnancy, those with impaired placental function are more susceptible to hypoxic events leading to increased mortality, serious short-term morbidity and long-term neurodevelopmental delays including neonatal encephalopathy and cerebral palsy.Doppler assessment of fetal blood flow and fetal growth are effective methods to evaluate fetal wellbeing. The umbilical artery pulsatility index can identify growth restriction from suboptimal placentation. The middle cerebral artery pulsatility index can identify the "brain sparing" effect caused by increased perfusion of the fetal brain. The ratio of these two measures (middle cerebral artery pulsatility index/umbilical artery pulsatility index) known as the cerebroplacental ratio has been suggested to be a better predictor than the individual components. This thesis will investigate the associations between maternal and perinatal factors and adverse perinatal outcomes. It will assess Doppler indices for the identification of fetal growth restrictedsmall for gestational age fetuses and those at risk of emergency caesarean for non-reassuring fetal status. The creation of accurate reference centiles using the generalised additive model for location, scale and shape approach, will allow for meaningful interpretation of those Doppler measurements. This information will be used to create predictive tools that will enable the clinician to identify pregnancies at risk of adverse perinatal outcomes and emergency caesarean for non-reassuring fetal status.iii

show abstract

Growth patterns of normo‐nourished Afghan, Haitian and Congolese children aged 6–59 months: A comparative study

et al. 2021

View full text Add to dashboard Cite

Objectives International growth charts have been used in the past decades to identify atypical growth and diagnose the nutritional status of individuals. The aim of this study was to construct and compare growth patterns of normo‐nourished children between 6–59 months from Afghanistan, Haiti, and the Democratic Republic of the Congo, to assess if it would be worth developing growth charts at a national level. Methods We used an international sample of 46 466 subjects (53.7% female; 46.3% male) from the aforementioned regions. To create the growth charts, we used different statistical methodologies: the Lambda‐Mu‐Sigma (LMS), LMSP, and LMST models, and regression models based on fractional polynomials. The LMSP models were the ones that fitted our data best and were therefore the ones used to make comparisons between countries using percentiles (3rd, 50th, and 97th). Results We found that Haitian children were both, taller and heavier than their Afghan and Congolese equals of the same ages. Moreover, differences were bigger in the highest percentiles (i.e., 97th percentile). These differences might be the result of the influence that genetics and diverse social and environmental contexts have on growth rates. Conclusions Using the same international reference standards for all populations could result in the overestimation or underestimation of the proportion of malnourished children. In light of our results, we recommend the future development of national and regional growth charts to provide health workers with more precise tools to evaluate the nutritional status in the child population.

show abstract

Design and other methodological considerations for the construction of human fetal and neonatal size and growth charts

Cited by 33 publications

References 80 publications

Four papers on child growth modelling

Four papers on child growth modelling

Maternal and perinatal factors associated with adverse perinatal outcomes at term and the development of a predictive model for identification of at–risk pregnancies.

Growth patterns of normo‐nourished Afghan, Haitian and Congolese children aged 6–59 months: A comparative study

Contact Info

Product

Resources

About