Design and Optimization of Self Nano-Emulsifying Drug Delivery System Containing a New Anti-inflamatory Agent Pentagamavunon-0

Abstract

Pentagamavunon-0 is a potent anti-inflammatory drug. The oral bioavailability of PGV-0 is very low due to its low solubility in water. The aim of this study is to design and optimize SNEDDS formulation to improve dissolution of ABSTRAK Pentagamavunon-0 merupakan obat anti-inflamasi yang poten. Ketersediaan hayati PGV-0 sangat rendah dikarenakan kelarutannya yang rendah dalam air. Tujuan studi ini adalah untuk mendesain dan mengoptimasi sebuah formula SNEDDS untuk meperbaiki disolusi PGV-0 dengan menggunakan Simplex Lattice Design. sebagai variabel tetap adalah jumlah asam oleat (X1), Tween 20 dan labrasol (X2), dan PEG 400 (X3). Sebagai variabel tergantung adalah ukuran droplet (Y1), konsentrasi PGV-0 yang terlarut pada menit ke-45 (C45) (Y2) dan kelarutan

Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System

“…Referring to the previous reports (Astuti, 2017), the best oil, surfactant, and cosurfactant for PGV-0 SNEDDS formulation was oleic acid, tween 20:labrasol (1:1), and PEG 400, respectively. The selected excipient showed the highest ability to dissolve PGV-0.…”

“…The excipients selection for the PGV-0 SNEDDS formulation was reported by Astuti (2017). Briefly, the excipients were selected based on the ability to dissolve PGV-0 and self-nanoemulsifying properties.…”

“…The dispersability, the time to complete emulsification and any phase separation were evaluated visually. The % transmittance of the emulsion was measured by visible-spectrophotometric method (Astuti, et al, 2017).…”

“…Referring to the previous work (Astuti, 2017), the optimized PGV-0 SNEDDS formulation was prepared by using oleic acid, tween 20:labrasol (1:1) and PEG 400 as oil, surfactant, and cosurfactant, respectively. In a glass vial, a mixture of oleic acid (1.86 mL), tween 20:labrasol (1:1) (5.14 mL), and PEG 400 (3mL) was vortexed for 1min until homogenous.…”

“…The emulsion showed a transparent appearance with the highest % transmittance, i.e 92.88%, 92.75% and 93.90% in water, AGF and AIF, respectively. The optimum formulation obtained based on the desirability value showed the optimum ability to dissolve PGV-0, droplet size and C45 (Astuti, 2017).…”