“…Studies have shown that Quinazoline and its derivatives, which belong to organic heterocyclic compounds, possess a broad range of biopharmaceutical activities, including anti-inflammation [ 19 ], antimicrobial [ 20 , 21 ], antimetabolic syndrome [ 22 , 23 , 24 ], anti-convulsant [ 25 , 26 ] and anti-psychotics activity [ 27 ]. In recent years, quinazoline derivatives have been developed as drugs against different tumors, including FDA-approved erlotinib, gefitinib, vandetanib and lapatinib [ 28 , 29 , 30 , 31 , 32 ].…”