“…They included a number of additional supply chain type constraints such as single sourcing, internal sourcing, and transportation times. Ryu and Pistikopoulos (2005) presented an MILP model for the design of enterprisewide supply chains in the chemical industry. In a similar effort, Bok et al (2000) extended the work by Norton and Grossmann (1994) to incorporate operational decisions, such as inventory profile, changeover cost, and intermittent supplies over multiple operating sites, over a short term horizon.…”