Design and Methods of Nonclinical Hematotoxicity Studies

Reagan, William J.; Rovira, Armando R. Irizarry

doi:10.1002/9781119500537.ch10

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Focal changes in the sub‐membrane cytoskeleton may predispose mammalian acanthocyte formation, with alterations in the Band 3 protein, responsible for maintaining the connection between the erythro‐membrane and the sub‐membrane cytoskeleton, being a possible factor [8]. Changes in the phosphorylation status of Band 3 have also been observed [158].…”

Section: Types Of Poikilocytosis In Fishmentioning

confidence: 99%

Visualization of poikilocytosis as an emerging erythrocytic biomarker for fish health assessment

Bardhan,

Abraham,

Das

et al. 2024

Animal Research and One Health

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Fish health assessment is essential for maintaining sustainable aquatic ecosystems and ensuring the well‐being of wild and farmed fish populations. Hematological parameters are crucial indicators of fish health, with poikilocytosis emerging as a fundamental marker with significant diagnostic value. Poikilocytosis refers to abnormally shaped erythrocytes in bloodstream, reflecting underlying physiological and pathological conditions. Poikilocytosis can occur in various fish species and can be influenced by environmental stressors, infectious agents, nutritional deficiencies, and exposure to pollutants. Morphological alterations in erythrocytes, such as acanthocytes, echinocytes, dacrocytes, schistocytes, spherocytes, and codocytes are common poikilocytes in fish. Understanding the relationship between poikilocytosis and fish health has important implications for disease diagnosis, monitoring, surveillance, and management. By quantifying poikilocytic changes, researchers and veterinarians can differentiate normal variations from pathological conditions, facilitating targeted interventions and treatment strategies. While most studies have focused on heavy metal toxicity, stressors, nutritional deficiencies, pollutants, and therapeutics, the etiological induction of poikilocytosis in fish health has been overlooked. Nonetheless, poikilocytosis remains a valuable biomarker for assessing fish health and their environment. This review highlights piscine poikilocytosis as a significant fish hematological biomarker and its importance in understanding their health and culture conditions.

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Section: Types Of Poikilocytosis In Fishmentioning

confidence: 99%

Visualization of poikilocytosis as an emerging erythrocytic biomarker for fish health assessment

Bardhan,

Abraham,

Das

et al. 2024

Animal Research and One Health

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show abstract

“…Kucing yang mengalami kejadian rhinitis dapat menunjukkan gejala klinis yang beragam seperti bersin, batuk, demam, mengalami kelainan bernapas (nafas cepat atau melambat): keluamya leleran dari rongga hidung, hipersalivasi, selain itu selaput lendir hidung akan terlihat kemerahan dan diikuti pembengkakan limfonodus mandibularis (Eldredge et al, 2008). Pembengkakan limfonodus terjadi akibat sel-sel yang melawan infeksi dan cairan menumpuk (Hidayati et al, 2021) (Reagan et al, 2019). Monositosis menciri dengan meningkatnya kebutuhan jaringan untuk proses fagositosis partikel, atau pada kondisi yang berhungan dengan imunitas seluler, dan peradangan yang sedang berjalan akut atau kronis (Salasia dan Hariono, 2010;Harvey, 2012).…”

Section: Pembahasanunclassified

Chronic Rhinitis in Cat

Sulthanah,

Soma,

Putriningsih

2023

Vet.Sci.Med.J.

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A rescue female cat named Hanji aged 2 years with a body weight of 2.3 kg was examined at the Veterinary Internal Medicine Laboratory, Faculty of Veterinary Medicine, Udayana University. The purpose of the study was to diagnose, treat and evaluate the success of therapy in a case cat. Based on anamnesis, the cat had recurrent sneezing and nasal discharge and the cat had experienced eye pain so that the cat's left eye was broken and lost. On physical examination, there were oozing spots on both nostrils, sneezing and oozing. On palpation the right and left lymphonoduses were swollen, and on auscultation of the lungs there was stridor or abnormal lung sounds in general. Skin and nails, limbs, musculoskeletal, circulation, nerves, urogenital, and mucosa were normal. Supporting examination by conducting hematological examination, test kit, and isolation of bacterial and fungal identification. The test kit results showed that the case cat was negative for calicivirus infection or rhinotracheitis. The case cat was diagnosed with chronic rhinitis with a prognosis of fausta from the series of examinations performed. The therapy given to the case cat consisted of anti-inflammatory methylprednisolone (4 mg preparation, given orally (PO) with ½ tab once a day for 5 days), antibiotic doxycycline (100 mg preparation, given PO once a day for 6 days with ¼ tab, and supportive therapy in the form of vitamins and feed supplementation. On the 8th day of therapy showed success in treating chronic rhinitis and the eyes had begun to dry out. After supporting examinations such as negative test kit results showed no other indications such as Feline Calicivirus (FCV) or Feline Herpesvirus (FHV) disease so that the case animal was diagnosed with chronic rhinitis due to Chlamydia felis infection. Advice to owners if there are animals experiencing similar symptoms, immediately take them to the veterinarian for treatment so that the infection does not continue and severe and always maintain animal hygiene and surroundings.

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“…Parameter hematologi rutin adalah complete blood count (CBC). Variabel yang diamati berdasarkan rekomendasi Komite Koordinasi Internasional untuk Patologi Klinis meliputi: profil eritrosit, yaitu jumlah eritrosit, hemoglobin, hematokrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), dan mean corpuscular hemoglobin konsentrasi (MCH); Profil sel darah putih, yang merupakan penjumlahan diferensial jumlah sel darah putih yang terdiri dari neutrofil, limfosit, monosit, eosinofil, dan basofil, dan profil trombosit, yang merupakan perhitungan jumlah trombosit dan volume trombosit rata-rata (MPV) (Reagan et al, 2010).Meningkatnya permintaan pemeriksaan hitung trombosit, maka tidak lagi dilakukan secara manual melainkan secara otomatis dengan alat Hematology Analyzer. Metode pemeriksaan hitung jumlah trombosit yang digunakan adalah metode impedansdan optik.…”

Section: Pendahuluanunclassified

Perbedaan Pemeriksaan Hitung Jumlah Trombosit Metode Impedans dan Optik pada Pasien Mikrositosis

Setyowati¹,

Najmi²,

Apriani³

2022

jsi

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Ada dua metode untuk menghitung trombosit secara otomatis, yaitu metode impedansi dan metode optik, dan prinsipnya berbeda. Prinsip kerja dari metode impedansi adalah resistansi atau hambatan baterai tergantung pada pengaruh volume baterai terhadap arus tinggi, semakin besar baterai, semakin besar resistansi dan sebaliknya. Prinsip metode optik adalah hamburan cahaya yang terjadi ketika sel mengalir melalui celah dan berkas difokuskan ke area penginderaan di aperture/orifice. Penelitian ini bertujuan untuk mengetahui perbedaan jumlah trombosit yang diperiksa dengan metode impedansi dan optik pada pasien dengan mikrositosis di laboratorium klinik utama Bio Medika. Penelitian dilakukan mulai September 2019 hingga Oktober 2019. Sampel yang digunakan dalam penelitian ini adalah 122 pasien dari laboratorium klinik utama Bio Medika. Data yang diperoleh diuji normalitasnya kemudian diolah menggunakan uji statistik Wilcoxon. Dari hasil uji beda diperoleh p-value sebesar 0,000 (<0,05) yang berarti terdapat perbedaan nilai pemeriksaan impedansi dan optical platelet count pada pasien mikrositosis di laboratorium klinik utama Bio Medika. Jumlah trombosit metode impedansi lebih tinggi daripada metode optik. Kesimpulan Metode optik untuk jumlah trombosit pada pasien dengan mikrositosis

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Design and Methods of Nonclinical Hematotoxicity Studies

Cited by 3 publications

References 20 publications

Visualization of poikilocytosis as an emerging erythrocytic biomarker for fish health assessment

Visualization of poikilocytosis as an emerging erythrocytic biomarker for fish health assessment

Chronic Rhinitis in Cat

Perbedaan Pemeriksaan Hitung Jumlah Trombosit Metode Impedans dan Optik pada Pasien Mikrositosis

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