Design and manufacture of functional catalyst-carrier structures for the bioorthogonal activation of anticancer agents

Abstract

Achieving the activation of a latent prodrug via bio-orthogonal chemistry on the catalytic surface of a tailored Ti-[Pd] device.

Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions

“…Strategies to boost the activity of Pd in certain reactions have been devised by introducing additional transition metals such as Ti. In this direction, a drug‐eluting system that can be implanted inside tumors to release cytotoxic agents only at the disease tissue was developed by Rubio‐Ruiz [50] . It consisted of a Ti substrate coated with metallic Pd that was prepared by the magnetron sputtering method and demonstrated high catalytic efficiency for the uncaging of a prodye to generate fluorescent Rh110 upon Pd‐mediated O depropargylation.…”

Transition Metal Scaffolds Used To Bring New‐to‐Nature Reactions into Biological Systems

“…Overall, the developed Pd‐, Au‐, and Cu‐resins have been used with great effect for in vivo catalytic purposes (notably with zebrafish) for various prodrug activation and imaging purposes. And although not highlighted in this review due to unspecified sizes, other investigations have also looked at the biocompatibility and catalytic ability of transition metals encased within hydrogel frameworks, [322] as well as sintered titanium devices [323] …”

“…And although not highlighted in this review due to unspecified sizes, other investigations have also looked at the biocompatibility and catalytic ability of transition metals encased within hydrogel frameworks, [322] as well as sintered titanium devices. [323] Overall, there have been a diverse range of scaffold compositions and sizes that researchers have employed to develop nanocarriers capable of in vivo catalysis. At the moment, it would be difficult to objectively compare their viability or to gauge their translational potential to humans.…”

Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization

“…In an emerging eld of study, researchers have extensively investigated metal-based uncaging of drugs/uorophores applicable in cell-or animal-based models. 3 Mainly employing metals like palladium and ruthenium, a number of examples have leaned heavily on some iteration of amine/alcohol release through masking groups that include azide, [4][5][6][7] allene, 8 allyl, 9,10 propargyl, [11][12][13][14][15][16][17][18][19][20][21][22] propargyloxycarbonyl (Proc), [19][20][21][22][23][24][25][26][27][28][29] and allyloxycarbonyl (Alloc). [10][11][12][28][29][30][31][32][33][34][35][36][37][38][39][40] Looking at current literature, a few areas of need can be clearly identied.…”