Design and investigation of salecan/chitosan hydrogel formulations with improved antibacterial performance and 3D cell culture function

Fan, Zhiping; Cheng, Ping; Wang, Dawei; Zhao, Yanna; Wang, Zhengping; Han, Jun

doi:10.1080/09205063.2020.1800907

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Hydrogels have been extensively researched and applied in regenerative medicine [45][46][47][48], 3D cultures [49][50][51] and sustained-release drug delivery systems [48,[52][53][54]. Skin regeneration is a great clinical challenge for wound healing.…”

Section: Research Progress Of Hydrogelmentioning

confidence: 99%

Application of Hydrogels as Sustained-Release Drug Carriers in Bone Defect Repair

Feng

Guo

et al. 2022

Polymers

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Large bone defects resulting from trauma, infection and tumors are usually difficult for the body’s repair mechanisms to heal spontaneously. Generally, various types of bones and orthopedic implants are adopted to enhance bone repair and regeneration in the clinic. Due to the limitations of traditional treatments, bone defect repair is still a compelling challenge for orthopedic surgeons. In recent years, bone tissue engineering has become a potential option for bone repair and regeneration. Amidst the various scaffolds for bone tissue engineering applications, hydrogels are considered a new type of non-toxic, non-irritating and biocompatible materials, which are widely used in the biomedicine field currently. Some studies have demonstrated that hydrogels can provide a three-dimensional network structure similar to a natural extracellular matrix for tissue regeneration and can be used to transport cells, biofactors, nutrients and drugs. Therefore, hydrogels may have the potential to be multifunctional sustained-release drug carriers in the treatment of bone defects. The recent applications of different types of hydrogels in bone defect repair were briefly reviewed in this paper.

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Section: Research Progress Of Hydrogelmentioning

confidence: 99%

Application of Hydrogels as Sustained-Release Drug Carriers in Bone Defect Repair

Feng

Guo

et al. 2022

Polymers

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“…Furthermore, salecan was compounded with polymers from natural resources such as agarose [ 22 ], chitosan [ 23 , 24 ], gelatin [ 25 ], κ-carrageenan [ 26 ], gellan gum [ 27 ] or soy protein isolate [ 28 ], targeting cell-culture applications, the sustained release of drugs (vancomycin, vitamin C) or envisaging tissue engineering applications, respectively.…”

Section: Introductionmentioning

confidence: 99%

Novel Green Crosslinked Salecan Hydrogels and Preliminary Investigation of Their Use in 3D Printing

et al. 2023

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Salecan, a kind of polysaccharide, is produced by the Agrobacterium ZX09 salt tolerant strain. In this study, green crosslinked citric acid-salecan hydrogels are explored as novel materials with a high potential for use in regenerative medicine. The impact of salecan and citric acid on the final crosslinked hydrogels was intensively studied and estimated in terms of the whole physicochemical properties and antimicrobial activity. FTIR spectra demonstrated the successful green crosslinking of salecan through its esterification with citric acid where the formation of strong covalent bonds collaboratively helped to stabilize the entire hydrogel systems in a wet state. Hydrogels presented a microporous morphology, good swelling capacity, pH responsiveness, great mechanical stability under stress conditions and good antibacterial activity, all related to the concentration of the biopolymers used in the synthesis step. Additionally, salecan hydrogels were preliminary investigated as printing inks. Thanks to their excellent rheological behavior, we optimized the citrate-salecan hydrogel inks and printing parameters to render 3D constructs with great printing fidelity and integrity. The novel synthesized salecan green crosslinked hydrogels enriches the family of salecan-derived hydrogels. Moreover, this work not only expands the application of salecan hydrogels in various fields, but also provides a new potential option of designing salecan-based 3D printed scaffolds for customized regenerative medicine.

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Antibacterial noncytotoxic chitosan coatings on polytetrafluoroethylene films by plasma grafting for medical device applications

et al. 2022

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Design and investigation of salecan/chitosan hydrogel formulations with improved antibacterial performance and 3D cell culture function

Cited by 4 publications

References 37 publications

Application of Hydrogels as Sustained-Release Drug Carriers in Bone Defect Repair

Application of Hydrogels as Sustained-Release Drug Carriers in Bone Defect Repair

Novel Green Crosslinked Salecan Hydrogels and Preliminary Investigation of Their Use in 3D Printing

Antibacterial noncytotoxic chitosan coatings on polytetrafluoroethylene films by plasma grafting for medical device applications

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