Design and in vivo evaluation of alginate-based pH-sensing electrospun wound dressing containing anthocyanins

Pakolpakçıl, Ayben; Osman, Bilgen; Göktalay, Gökhan; Özer, Elif Tümay; Şahan, Yasemin; Beceri̇r, Behçet; Karaca, Esra

doi:10.1007/s10965-020-02400-1

Cited by 55 publications

(34 citation statements)

References 62 publications

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“…It can be assumed that bee pollen decreased the segmental mobility of the polymer, thus inflexible groups increased Tg of nanofibrous material. Bee pollen molecules contain carboxyl groups [ 47 , 48 ] and PVA molecules contain hydroxyl groups [ 36 , 41 ]. It is thought that hydrogen bonds are formed between these two groups.…”

Section: Discussionmentioning

confidence: 99%

“…The melting temperature (Tm) of the SA/PVA, 1BP-SA/PVA, 2BP-SA/PVA, and 3BP-SA/PVA nanofiber samples was determined to be around 196 °C, 192 °C, 190 °C, and 196 °C, respectively. The characteristic peaks of the SA/PVA nanofiber were observed at 3310 cm −1 , 2941 cm −1 , 1732 cm −1 , and 1091 cm −1 were assigned to OH groups, CH stretching, and CO stretching, respectively [36,41]. The characteristic peaks of the electrospun bee pollenloaded SA/PVA nanofibers (1BP-SA/PVA and 3BP-SA/PVA) were observed at 3310 cm −1 , 2939 cm −1 , 1732 cm −1 , and 1088 cm −1 were assigned to OH groups, CH stretching and CO stretching, respectively.…”

Section: Dsc Analysismentioning

confidence: 99%

“…Because of its structural similarities to the extracellular matrix, and its gelling properties under conditions compatible with biological activities, it is widely used in biomedical engineering applications, for example, drug delivery, in vitro cell culture, wound healing, and tissue engineering [ 31 , 32 , 33 ]. Electrospun alginate-based nanofibers have been developed for use in biomedical applications such as wound dressing [ 34 , 35 , 36 ], tissue engineering [ 37 , 38 ], and drug delivery systems [ 39 , 40 ]. The SA polymer in a water-based solution cannot be electrospun alone due to its inadequate chain entanglements.…”

Section: Introductionmentioning

confidence: 99%

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Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat

Pakolpakçıl

Draczyński

2021

Materials

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Green electrospun materials are gaining popularity in the quest for a more sustainable environment for human life. Bee pollen (BP) is a valuable apitherapeutic product and has many beneficial features such as antioxidant and antibacterial properties. Alginate is a natural and low-cost polymer. Both natural materials show good compatibility with human tissues for biomedical applications and have no toxic effect on the environment. In this study, bee pollen-loaded sodium alginate and polyvinyl alcohol (SA/PVA) nanofibrous mats were fabricated by the electrospinning technique. The green electrospun nanofibrous mats were analyzed by scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), and differential scanning calorimeter (DSC). According to the findings of the study, the toxin-free electrospinning method is suitable for producing green nanomaterial. Because of the useful properties of the bee pollen and the favorable biocompatibility of the alginate fibers, the bee pollen-loaded SA/PVA electrospun mats have the potential for use in a variety of biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Dsc Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat

Pakolpakçıl

Draczyński

2021

Materials

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“…Despite this, superior electrical conductivity poses difficulties since the solution does not possess adequate charge repulsion to overcome its surface tension [66]. Several studies have reported an increase in conductivity upon incorporating anthocyanin into the polymer solution and higher elongation of jet and fibers with a smaller diameter [67][68][69].…”

Section: Electrospraying/electrospinningmentioning

confidence: 99%

Microencapsulation of Anthocyanins—Critical Review of Techniques and Wall Materials

Mohammadalinejhad

Kurek

2021

Applied Sciences

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Anthocyanins are value-added food ingredients that have health-promoting impacts and biological functionalities. Nevertheless, there are technological barriers to their application in the food industry, mainly because of their poor stability and susceptibility to harsh environmental conditions, such as oxygen, temperature, pH, and light, which could profoundly influence the final food product′s physicochemical properties. Microencapsulation technology is extensively investigated to enhance stability, bioaccessibility, and impart controlled release properties. There are many varieties of microencapsulation methods and diverse types of wall materials. However, choosing a proper approach involves considering the processing parameters, equipment availability, and application purposes. The present review thoroughly scrutinizes anthocyanins′ chemical structure, principles, benefits, and drawbacks of different microencapsulation methods, including spray drying, freeze drying, electrospinning/electrospraying, inclusion complexes, emulsification, liposomal systems, ionic gelation, and coacervation. Furthermore, wall materials applied in different techniques plus parameters that affect the powders′ encapsulation efficiency and physicochemical properties are discussed. Future studies should focus on various processing parameters and the combination of different techniques and applications regarding microencapsulated anthocyanins in functional foods to assess their stability, efficiency, and commercialization potentials.

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“…Natural bioactive agents have been used in biomedical due to their significant contribution since ancient times. Lately, the use of natural compounds such as plant extracts [21][22][23], bee products [24][25][26], and oils [27][28][29] for developing electrospun fibrous materials in biomedical applications has been studied extensively. Hypericum perforatum, a member of the Hypericaceae family, has long been regarded as a valuable herbal medicine.…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Study of Antibacterial Properties of Electrospun Hypericum perforatum Oil-Loaded Poly(lactic Acid) Nonwovens for Potential Biomedical Applications

et al. 2021

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The growth of population and increase in diseases that cause an enormous demand for biomedical material consumption is a pointer to the pressing need to develop new sustainable biomaterials. Electrospun materials derived from green polymers have gained popularity in recent years for biomedical applications such as tissue engineering, wound dressings, and drug delivery. Among the various bioengineering materials used in the synthesis of a biodegradable polymer, poly(lactic acid) (PLA) has received the most attention from researchers. Hypericum perforatum oil (HPO) has antimicrobial activity against a variety of bacteria. This study aimed to investigate the development of an antibacterial sustainable material based on PLA by incorporating HPO via a simple, low-cost electrospinning method. Chemical, morphological, thermal, thickness and, air permeability properties, and in vitro antibacterial activity of the electrospun nonwoven fabric were investigated. Scanning electron microscopy (SEM) was used to examine the morphology of the electrospun nonwoven fabric, which had bead-free morphology ultrafine fibers. Antibacterial tests revealed that the Hypericum perforatum oil-loaded poly(lactic acid) nonwoven fabrics obtained had high antibacterial efficiency against Escherichia coli and Staphylococcus aureus, indicating a strong potential for use in biomedical applications.

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Design and in vivo evaluation of alginate-based pH-sensing electrospun wound dressing containing anthocyanins

Cited by 55 publications

References 62 publications

Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat

Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat

Microencapsulation of Anthocyanins—Critical Review of Techniques and Wall Materials

An In Vitro Study of Antibacterial Properties of Electrospun Hypericum perforatum Oil-Loaded Poly(lactic Acid) Nonwovens for Potential Biomedical Applications

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