Design and In Situ Characterization of Lipid Containers with Enhanced Drug Retention

Abstract

Vesosome with distinct interior (green, orange) and exterior (blue) bilayer membranes. Drugs are encapsulated within the interior compartments and are protected from blood serum components by the exterior membrane. The outer membrane can be decorated with PEG lipids (red) to prevent aggregation in the blood as well as specific labels or targeting ligands.

Polymersomes in Polymersomes: Multiple Loading and Permeability Control

“…This double-membrane effect was demonstrated by observing the serum half-life of ciprofloxacin drug increasing from 10 min in single liposomes to 6 h in vesosomes. [7] Other reports evidenced the biomedical impact of such vesosomes for transcutaneous, [8] and oral administration, [9] important areas in drug delivery and cancer therapy. More complex or compartmentalized structures in general, have started to appear because they enable an unprecedented level of control, in particular in the fields of drug delivery [10] and confined reactors.…”

Inside-outside self-assembly of light-activated fast-release liposomes

“…Efficient encapsulation of the CuS nanoparticles into liposomes was done by taking advantage of the interdigitated phase of DPPC and similar saturated phospholipids 6, 8, 9, 39 (Fig. 3).…”

“…An optimal carrier would retain its contents without loss until the time and place that release is desired at some user-defined optimal rate. However, for a single bilayer liposome, it has proven difficult to switch from contents retention to varied levels of contents release, or switch from fast release back to contents retention on command 1–9 . In drug delivery applications, for example, liposomes begin distributing into various organs and the tumor and are also eliminated from the blood following intravenous injection 12 .…”

Differential Scanning Calorimetry Studies of Phospholipid Membranes: The Interdigitated Gel Phase

“…Therefore, vesosomes have the potential to more closely mimic biological conditions and reactions in artificial cells [150,154,155]. Furthermore, the retention of encapsulated material can be substantially increased in vesosomes [151,156,157]. These vesicles are highly customizable because the composition of the inner and outer components can be varied [149,150,154].…”