Art education is important to the overall development of children, and art training can start from improving children’s art appreciation and perception. In this study, we built an interactive painting synthesis system for children’s art education to let them know about world famous paintings and art history. The interactive learning systems can provide engaging ways of art education based on image synthesis, style transfer and animation generation technology. Specifically, an image dataset of famous paintings was established for painting synthesis and an application “ARTIST” was developed based on First Order Motion Method. The system “ARTIST” can attract children’s active participation via interesting art creation interaction and enhance their learning motivation in their exploration.