Design and Implementation of a Rodent Voluntary Wheel-Running Exercise Facility Incorporating Dynamically Controllable Torque Load

Guillemin, Bernard; Smith, Harrison

doi:10.1109/tim.2006.873812

Cited by 2 publications

(2 citation statements)

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“…The rats of both running wheel groups had free access to a specially designed running wheel system (Guillemin & Smith, 2006). This model of voluntary resistance wheel running is physiological (loads muscles in a functional manner), non‐invasive and practical, with controllable and precise resistance loading and comprehensive monitoring (speed, distance and duration of each bout, monitored continuously) of the activity performed.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, using a system of dynamic torque loading on the running wheel (Guillemin & Smith, 2006), we applied a progressively increasing resistance protocol with much higher loads (up to the equivalent of a static load of ∼173% of body mass) in comparison to those previously described (Ishihara et al 1998, 2002; Konhilas et al 2005). Since the activity pattern is a crucial factor in determining the expected physiological adaptations, the aims of this study were twofold: firstly, to characterize the pattern of voluntary activity in response to progressive resistance loading on running wheels; and, secondly, to determine the effects of resistance running wheel activity on muscle hypertrophy of six limb skeletal muscles in young rats.…”

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confidence: 99%

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Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats

Legerlotz

Elliott

Guillemin

et al. 2008

Experimental Physiology

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The aims of this study were to characterize the pattern of voluntary activity of young rats in response to resistance loading on running wheels and to determine the effects of the activity on the growth of six limb skeletal muscles. Male Sprague-Dawley rats (4 weeks old) were housed individually with a resistance running wheel (R-RUN, n = 7) or a conventional free-spinning running wheel (F-RUN, n = 6) or without a wheel, as non-running control animals (CON, n = 6). The torque required to move the wheel in the R-RUN group was progressively increased, and the activity (velocity, distance and duration of each bout) of the two running wheel groups was recorded continuously for 45 days. The R-RUN group performed many more, shorter and faster bouts of running than the F-RUN group, yet the mean daily distance was not different between the F-RUN (1.3 ± 0.2 km) and R-RUN group (1.4 ± 0.6 km). Only the R-RUN resulted in a significantly (P < 0.05) enhanced muscle wet mass, relative to the increase in body mass, of the plantaris (23%) and vastus lateralis muscle (17%), and the plantaris muscle fibre crosssectional area, compared with CON. Both F-RUN and R-RUN led to a significantly greater wet mass relative to increase in body mass and muscle fibre cross-sectional area in the soleus muscle compared with CON. We conclude that the pattern of voluntary activity on a resistance running wheel differs from that on a free-spinning running wheel and provides a suitable model to induce physiological muscle hypertrophy in rats.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%