Design and Hydrodynamic Characterization of a Draft Tube Baffle Tank for Lab‐Scale

Schmalenberg, Mira; Nocon, Anna‐Katharina; Kockmann, Norbert

doi:10.1002/cite.201900078

Cited by 5 publications

(3 citation statements)

References 31 publications

(35 reference statements)

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“…Another equipment that is down-scaled to fulfill the requirements of continuous smallscale crystallization [37][38][39], is the draft tube baffle (DTB) crystallizer which is well known for many industrial applications [1,40]. Usually used for vacuum crystallization, it can also successfully be used in cooling crystallization applications.…”

Section: Cascaded Vesselsmentioning

confidence: 99%

Small-Scale Solids Production Plant with Cooling Crystallization, Washing, and Drying in a Modular, Continuous Plant

Höving,

Schmidt,

Peters

et al. 2023

Processes

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Small-scale continuous apparatuses for solid product manufacturing are receiving increasing interest due to the demand for the fast market availability of specialty chemical products manufactured in integrated and modular processing plants. Relevant unit operations span from crystallization over solid–liquid separation and filter cake washing to drying. For this purpose, the quasi-continuous filter belt crystallizer (QCFBC) was developed and is presented here. The newly integrated unit operations with positive pressure filtration (Δpmax = 0.8 bar), filter cake washing (V˙wash = 55 mL·min−1), and convection drying (Tdry = 60 °C) have been individually characterized and integrated into the filter apparatus that has been modified for continuous operation. They were synchronized with the flexible cooling crystallization, enabling for a seamless production process. Sucrose in water was used as model substance system. Long-term operations of up to 14 h were successfully performed with dry product filter cakes (22.64 g ± 1.64 g·h−1) of constant quality attributes (x50,3 = 216.095 ± 14.766, span = 0.347 ± 0.109, Yrel. = 69.9% ± 5%, XRM = 1.64 mg·g−1 ± 1.38 mg·g−1).

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Section: Cascaded Vesselsmentioning

confidence: 99%

Small-Scale Solids Production Plant with Cooling Crystallization, Washing, and Drying in a Modular, Continuous Plant

Höving,

Schmidt,

Peters

et al. 2023

Processes

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“…Most recently, our group has scaled down a continuously operated draft tube baffle (DTB) crystallizer from 1100‐L pilot scale to 1.2‐L lab scale. The geometrical similarity scales from 1:8 to 1:12, depending on the suspension flow and sufficiently high free cross section for the crystals.…”

Section: Design Guidelines For Small‐scale Equipmentmentioning

confidence: 99%

Equipment and Separation Units for Flow Chemistry Applications and Process Development

et al. 2019

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Process development and small‐scale production gets more and more important in fine chemistry and pharmaceutical production. An equipment toolbox assists process synthesis presented in this contribution. A microfluidic calorimeter can measure kinetic and thermodynamic reaction data with commercial plate reactors. A tubular reactor coiled with 90° bends allows for long residence time with low axial dispersion, also known as coiled flow inverter (CFI). A similar setup is used for continuous‐flow cooling crystallization. Small‐scale columns with rotating internals are employed for distillation and liquid‐liquid extraction. Main emphasis will be put on automation and scale‐up in future steps.

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“…A known 1100 L DTB from literature, ref , was scaled down. , It was characterized regarding suspension and residence time behavior, and cooling crystallization experiments focused on the start-up procedure were made . However, during the cooling crystallization experiments, the product discharge tends to clog .…”

Section: Introductionmentioning

confidence: 99%

Continuous Miniaturized Draft Tube Baffle Crystallizer with Particle Screw for Supportive Suspension Discharge

Schmalenberg

Krell

Mathias

et al. 2021

Ind. Eng. Chem. Res.

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Continuous small-scale processes can enable faster process development and reduce time-to-market. However, for continuous crystallization, there are some hurdles, too, regarding suspension handling. Therefore, to overcome clogging issues concerning the product discharge, due to the smaller dimensions of a continuous draft tube baffle (DTB) crystallizer, a particle screw for supportive suspension discharge was developed and has been described throughout this work. First, the design of the particle screw is described. Furthermore, the particle screw is characterized, and cooling crystallization experiments (with L-alanine/water) are performed with a miniaturized (2 L) DTB. The presented particle screw showed negligible abrasion effects to the conveyed crystals. The investigations showed that the residence time of different particle sizes depends on the particle screw speed. Additionally, the continuous cooling crystallization experiments with 15 g min −1 confirm the supporting character of the suspension discharge by the particle screw. Thus, the newly developed particle screw for a supportive suspension discharge is well suited for continuous smallscale crystallization.

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Design and Hydrodynamic Characterization of a Draft Tube Baffle Tank for Lab‐Scale

Cited by 5 publications

References 31 publications

Small-Scale Solids Production Plant with Cooling Crystallization, Washing, and Drying in a Modular, Continuous Plant

Small-Scale Solids Production Plant with Cooling Crystallization, Washing, and Drying in a Modular, Continuous Plant

Equipment and Separation Units for Flow Chemistry Applications and Process Development

Continuous Miniaturized Draft Tube Baffle Crystallizer with Particle Screw for Supportive Suspension Discharge

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