Design and Functional Activity of Phosphopeptides with Potential Immunomodulating Capacity, Based on the Sequence of Grb2‐Associated Binder 1

Abstract

A cell membrane permeable phosphopeptide corresponding to the SHP-2 binding motif of Grb2-associated binder 1 (Gab1) interferes with the Gab1 adaptor-dependent functions and modulates B cell receptor-triggered intracellular signaling in B cell tumors.