Design and Flow Analysis of MEMS based Piezo-electric Micro Pump

Sateesh, Jasti; Sravani, K. Girija; Kumar, R. Akshay; Rao, K. Srinivasa

doi:10.1007/s00542-017-3563-x

Cited by 39 publications

(15 citation statements)

References 24 publications

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“…With this design a high pumping rate of up to 100 µL min −1 was reported to be theoretically feasible. Going forward to recent years, a theoretical design and simulation of a single piezoelectric micropump composed by zirconate titanate (PZT)-5H material, quartz and PDMS was reported by Sateesh et al (2018). Although piezoelectric pumps offer fast response times and high forces, high voltage needs and special care must be taken into account when mounting PZT discs.…”

Section: Mechanical Micropumpsmentioning

confidence: 99%

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Mendoza

Scilletta

Bellino

et al. 2020

Front. Bioeng. Biotechnol.

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In recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness and the greatest possible automation. Some of the factors that challenge conventional drug release include longterm treatments, narrow therapeutic windows, complex dosing schedules, combined therapies, individual dosing regimens, and labile active substance administration. In this sense, the emergence of micro-devices that combine mechanical and electrical components, so called micro-electro-mechanical systems (MEMS) can offer solutions to these drawbacks. These devices can be fabricated using biocompatible materials, with great uniformity and reproducibility, similar to integrated circuits. They can be aseptically manufactured and hermetically sealed, while having mobile components that enable physical or analytical functions together with electrical components. In this review we present recent advances in the generation of MEMS drug delivery devices, in which various micro and nanometric structures such as contacts, connections, channels, reservoirs, pumps, valves, needles, and/or membranes can be included in their design and manufacture. Implantable single and multiple reservoir-based and transdermalbased MEMS devices are discussed in terms of fundamental mechanisms, fabrication, performance, and drug release applications.

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Section: Mechanical Micropumpsmentioning

confidence: 99%

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Mendoza

Scilletta

Bellino

et al. 2020

Front. Bioeng. Biotechnol.

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“…In the preceding sections the effect of channel angles has been elucidated; in parallel it is crucial to calculate the number of pipes in the proposed design to achieve maximum reabsorption rate. In Figure 2C at position 1, applying the Bernoulli principle, the total energy of fluid at the opening of the proximal tubule is given by LHS part of Equation (12) and the total energy of fluid at the orifice of first pipe is given by RHS part of Equation (12). Now let us assume P 1 -P 2 = ph; p = ΔP/Δx = Pressure Differential; to find vʹ, we have to transport some parts of the equation from RHS to LHS Upon solving where h is the distance between the orifice of pipe and opening of proximal tube pipes and h F is the friction head loss.…”

Section: Channels Needed For the Designmentioning

confidence: 99%

“…The Organ-on-a-Chip concept is an emerging and promising technology in recent times, which showcases the developments toward early stage detection of diseases and malfunctioning of the human body. [11][12][13] Most of the researchers and scientists have already started concentrating to resolve the issues by replicating the major functions of the organs on a chip. However, mimicking human kidney function is found to be more difficult than other functions in many other organs.…”

mentioning

confidence: 99%

Recreating the size‐dependent reabsorption function of proximal convoluted tubule towards artificial kidney applications: Structural analysis and computational study

et al. 2020

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“…Revathi and Padmanabhan designed a valveless micropump with a composite piezoelectric actuator which showed the maximum outflow at an aspect ratio of 15 for a nozzle/diffuser [10]. Sateesh et al [11] designed and modelled a piezoelectrically actuated micropump with PZT-5h and Polydimethylsiloxane (PDMS) with an outflow rate of 0.029 μL s−1.…”

Section: Introductionmentioning

confidence: 99%

3-D Design and Simulation of a Piezoelectric Micropump

2019

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The objective of this paper is to carefully study the performances of a new piezoelectric micropump that could be used, e.g., for drug delivery or micro-cooling systems. The proposed micropump is characterized by silicon diaphragms, with a piezoelectric actuation at a 60 V input voltage, and by two passive valves for flow input and output. By means of a 3-D Finite Element (FE) model, the fluid dynamic response during different stages of the working cycle is investigated, together with the fluid–structure interaction. The maximum predicted outflow is 1.62 μL min − 1 , obtained at 10 Hz working frequency. The computational model enables the optimization of geometrical features, with the goal to improve the pumping efficiency: The outflow is increased until 2.5 μL min − 1 .

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Design and Flow Analysis of MEMS based Piezo-electric Micro Pump

Cited by 39 publications

References 24 publications

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Recreating the size‐dependent reabsorption function of proximal convoluted tubule towards artificial kidney applications: Structural analysis and computational study

3-D Design and Simulation of a Piezoelectric Micropump

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