Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)

Jessen, Frank; Spottke, Annika; Boecker, Henning; Brosseron, Frederic; Büerger, Katharina; Catak, Cihan; Fließbach, Klaus; Franke, Christiana; Fuentes, Manuel; Heneka, Michael T.; Janowitz, Daniel; Kilimann, Ingo; Laske, Christoph; Menne, Felix; Nestor, Peter J.; Peters, Oliver; Priller, Josef; Pross, Verena; Ramı́rez, Alfredo; Schneider, Anja; Speck, Oliver; Spruth, Eike Jakob; Teipel, Stefan J.; Vukovich, Ruth; Westerteicher, Christine; Wiltfang, Jens; Wolfsgruber, Steffen; Wagner, Michael; Düzel, Emrah

doi:10.1186/s13195-017-0314-2

Cited by 159 publications

(347 citation statements)

References 28 publications

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“…A total of 73 older adults comprising 25 HCs and 21 SCD, 16 MCI, and 11 ADD patients were recruited via the DELCODE study of the DZNE in Germany. SCD, MCI, and ADD were defined as previously described [8]. All patient groups (SCD, MCI, and ADD) were referrals, including self‐referrals, whereas HCs were recruited by standardized public advertisement.…”

Section: Methodsmentioning

confidence: 99%

“…All patient groups (SCD, MCI, and ADD) were referrals, including self‐referrals, whereas HCs were recruited by standardized public advertisement. For more information on subject inclusion criteria, refer to the study by Jessen et al [8]. All participants gave written informed consent before inclusion in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Whole‐brain T 1 ‐weighted fast low‐angle shot (FLASH) images were acquired using the following parameters: 0.75 × 0.75 × 0.75 mm 3 voxel size, 320 × 320 × 192 matrix, 5.56 ms echo time, 20 ms repetition time, 23° flip angle, 130 Hz/pixel bandwidth, 7/8 partial Fourier, and 13:50 min scan duration as previously reported [5]. For a full description of the MRI protocol, refer to the study by Jessen et al [8]. Images were sinc interpolated to 0.375 mm 3 resolution before manual segmentation of the LC.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we investigated how LC MRI contrast relates to the pathophysiology of AD, i.e., as determined using cerebrospinal fluid (CSF) biomarkers. Using first data from the DZNE Longitudinal Cognitive Impairment and Dementia (DELCODE) study [8], we assessed how LC contrast changes in individuals with subjective cognitive decline (SCD), mild cognitive impairment (MCI), Alzheimer's disease dementia (ADD), and age‐matched healthy controls (HCs) related to levels of CSF amyloid and tau. We hypothesized a decrease in LC MRI contrast in ADD due to loss of neuromelanin‐containing noradrenergic neurons would correlate with increased AD pathology.…”

Section: Introductionmentioning

confidence: 99%

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Locus coeruleus MRI contrast is reduced in Alzheimer's disease dementia and correlates with CSF Aβ levels

Betts

Cárdenas-Blanco

Kanowski

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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Introduction This study aimed to assess how interindividual differences in locus coeruleus (LC) magnetic resonance imaging (MRI) contrast relate to cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD). Methods LC MRI contrast was quantified in 73 individuals from the DZNE Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study comprising 25 healthy elderly adults and 21 individuals with subjective cognitive decline, 16 with mild cognitive impairment, and 11 participants with AD dementia using 3D T 1 -weighted fast low-angle shot (FLASH) imaging (0.75 mm isotropic resolution). Bootstrapped Pearson's correlations between LC contrast, CSF amyloid, and tau were performed in 44 individuals with CSF biomarker status. Results A significant regional decrease in LC MRI contrast was observed in patients with AD dementia but not mild cognitive impairment and subjective cognitive decline compared with healthy controls. A negative association between LC MRI contrast and levels of CSF amyloid but not with CSF tau was found. Discussion These results provide first evidence for a direct association between LC MRI contrast using in vivo T 1 -weighted FLASH imaging and AD pathology.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Locus coeruleus MRI contrast is reduced in Alzheimer's disease dementia and correlates with CSF Aβ levels

Betts

Cárdenas-Blanco

Kanowski

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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“…Visual memory tests were analyzed from the DZNE‐Longitudinal Cognitive Impairment and Dementia Study (DELCODE), an observational, longitudinal memory clinic–based study across 10 sites in Germany. Specific details about this study, the visual memory task, and data handling and quality control are reported in the studies by Jessen et al [14] and Düzel et al [15]. The data analyzed in this study were from the second data release of the DELCODE study comprising 700 individuals of which 394 participants with complete data sets were analyzed, including 136 participants with SCD, 65 with MCI, and 193 HCs.…”

Section: Methodsmentioning

confidence: 99%

Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment

Bainbridge

Berron

Schütze

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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Introduction Impaired long-term memory is a defining feature of mild cognitive impairment (MCI). We tested whether this impairment is item specific, limited to some memoranda, whereas some remain consistently memorable. Methods We conducted item-based analyses of long-term visual recognition memory. Three hundred ninety-four participants (healthy controls, subjective cognitive decline [SCD], and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs. Results We observed consistent memorability for images in healthy controls, SCD, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set. Discussion Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.

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Analysis of Psychological Symptoms Following Disclosure of Amyloid–Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline

et al. 2023

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ImportanceIndividuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some individuals with SCD+ undergo amyloid-positron emission tomography (PET) as part of research studies and frequently wish to know their amyloid status; however, the disclosure of a positive amyloid-PET result might have psychological risks.ObjectiveTo assess the psychological outcomes of the amyloid-PET result disclosure in individuals with SCD+ and explore which variables are associated with a safer disclosure in individuals who are amyloid positive.Design, Setting, and ParticipantsThis prospective, multicenter study was conducted as part of The Amyloid Imaging to Prevent Alzheimer Disease Diagnostic and Patient Management Study (AMYPAD-DPMS) (recruitment period: from April 2018 to October 2020). The setting was 5 European memory clinics, and participants included patients with SCD+ who underwent amyloid-PET. Statistical analysis was performed from July to October 2022.ExposuresDisclosure of amyloid-PET result.Main Outcomes and MeasuresPsychological outcomes were defined as (1) disclosure related distress, assessed using the Impact of Event Scale–Revised (IES-R; scores of at least 33 indicate probable presence of posttraumatic stress disorder [PTSD]); and (2) anxiety and depression, assessed using the Hospital Anxiety and Depression scale (HADS; scores of at least 15 indicate probable presence of severe mood disorder symptoms).ResultsAfter disclosure, 27 patients with amyloid-positive SCD+ (median [IQR] age, 70 [66-74] years; gender: 14 men [52%]; median [IQR] education: 15 [13 to 17] years, median [IQR] Mini-Mental State Examination [MMSE] score, 29 [28 to 30]) had higher median (IQR) IES-R total score (10 [2 to 14] vs 0 [0 to 2]; P &lt; .001), IES-R avoidance (0.00 [0.00 to 0.69] vs 0.00 [0.00 to 0.00]; P &lt; .001), IES-R intrusions (0.50 [0.13 to 0.75] vs 0.00 [0.00 to 0.25]; P &lt; .001), and IES-R hyperarousal (0.33 [0.00 to 0.67] vs 0.00 [0.00 to 0.00]; P &lt; .001) scores than the 78 patients who were amyloid-negative (median [IQR], age, 67 [64 to 74] years, 45 men [58%], median [IQR] education: 15 [12 to 17] years, median [IQR] MMSE score: 29 [28 to 30]). There were no observed differences between amyloid-positive and amyloid-negative patients in the median (IQR) HADS Anxiety (–1.0 [–3.0 to 1.8] vs –2.0 [–4.8 to 1.0]; P = .06) and Depression (–1.0 [–2.0 to 0.0] vs –1.0 [–3.0 to 0.0]; P = .46) deltas (score after disclosure – scores at baseline). In patients with amyloid-positive SCD+, despite the small sample size, higher education was associated with lower disclosure-related distress (ρ = –0.43; P = .02) whereas the presence of study partner was associated with higher disclosure-related distress (W = 7.5; P = .03). No participants with amyloid-positive SCD+ showed probable presence of PTSD or severe anxiety or depression symptoms at follow-up.Conclusions and RelevanceThe disclosure of a positive amyloid-PET result to patients with SCD+ was associated with a bigger psychological change, yet such change did not reach the threshold for clinical concern.

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Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)

Cited by 159 publications

References 28 publications

Locus coeruleus MRI contrast is reduced in Alzheimer's disease dementia and correlates with CSF Aβ levels

Locus coeruleus MRI contrast is reduced in Alzheimer's disease dementia and correlates with CSF Aβ levels

Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment

Analysis of Psychological Symptoms Following Disclosure of Amyloid–Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline

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