Design and Fabrication of Untethered Light-Actuated Microbots in Fluid for Biomedical Applications

Abstract

Untethered mobile robots at the micro-scale have the ability to improve biomedical research by performing specialized tasks inside complex physiological environments. Light-controlled wireless microbots are becoming the center of interest thanks to their accuracy in navigation and potential to carry out operations in a non-invasive manner inside living environments. The pioneering light-engineered microbots are currently in the early stage of animal trials. There is a long way ahead before they can be employed in humans for therapeutic applications such as targeted drug delivery, cancer cell diagnosis, tissue engineering, etc. The design of light-actuated microbots is one of the challenging parts along with the biocompatibility and precision control for in vivo applications. Recent progress in light-activated microbots has revealed a few innovative design concepts. In this study, we presented a framework on the different aspects with a comparative analysis of potential designs for the next generation of light-controlled microbots. Utilizing numerical simulations of fluid-structure interactions, limiting design elements of the microbots are addressed. We envision that this study will eventually facilitate the integration of robotic applications into the real world owing to the described design considerations.

Light-Controlled Microbots in Biomedical Application: A Review

“…Based on the proper application of the light-actuated microbots, the factors must be set accordingly. For in vivo applications, biomaterial compatibility is an important factor of consideration, while in other operations such as micromanipulation or mixing of microfluidics, control and load-transport mechanisms are more important than the biocompatibility of material [73,136,137]. Different aspects of designing the microbots are explored in detail in the following sections.…”