Design and fabrication of transdermal drug delivery patch with milliprojections using material extrusion 3D printing

Tang, Tiffany Obog; Wong-Holmes, Susan; Dean, Katherine; Simon, George P.

doi:10.1002/app.48777

Cited by 26 publications

(22 citation statements)

References 44 publications

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“…( a – c ) Microneedles produced by FDM technology. Reproduced with permission from [ 26 , 32 , 117 ], Royal Society of Chemistry, London, UK, 2018 ( a ), Springer Nature, Basingstoke, UK, 2020 ( b ), and John/Wiley & Sons, Inc., Hoboken, NJ, USA, 2020 ( c ). The image was created with Adobe Illustrator CC (Version 23.0.1.; Adobe Inc., San Jose, CA, USA, 2019).…”

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

“…It was found that a thinner layer led to a more accurate tip, and a thinner infill width resulted in more accurate part diameters. It was also reported that the smaller nozzle orifice and increased spacing between MNs produced better surface finish but had no significant effect on part accuracy [ 117 ].…”

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

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3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

et al. 2021

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Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined.

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Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

et al. 2021

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“…[1][2][3][4][5][6] Various 3D printing techniques such as vat polymerization-based printing technologies which include stereolithography (SLA), digital light processing (DLP) and PolyJet technologies, and powder-based printing technologies which include selective laser sintering (SLS), selective laser melting (SLM), and electron beam melting (EBM) have been developed for different materials and applications. [7][8][9][10] Among these technologies, the vat polymerization printing technologies are the most accurate printing processes with excellent surface finishing, making them the best choice for medical devices printing. However, parts printed by technologies such as SLA and DLP are less durable and robust as compare to the ones printed by the powderbased printing technologies.…”

Section: Introductionmentioning

confidence: 99%

“…Particularly in the medical field, 3D printing provides an effective solution for dentures, orthotic and prosthetic components, surgical models, and hearing aids 1–6 . Various 3D printing techniques such as vat polymerization‐based printing technologies which include stereolithography (SLA), digital light processing (DLP) and PolyJet technologies, and powder‐based printing technologies which include selective laser sintering (SLS), selective laser melting (SLM), and electron beam melting (EBM) have been developed for different materials and applications 7–10 . Among these technologies, the vat polymerization printing technologies are the most accurate printing processes with excellent surface finishing, making them the best choice for medical devices printing.…”

Section: Introductionmentioning

confidence: 99%

Enhanced dispersion of hydroxyapatite whisker in orthopedics 3D printing resin with improved mechanical performance

Chong

Tan

Liu

et al. 2021

J of Applied Polymer Sci

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One-dimensional fillers such as rods and fibers have shown effective mechanical reinforcement in polymer nanocomposites, but their application in vat polymerization-based 3D printing techniques was hindered due to the rapidly increased viscosity of the resin. In order to improve the fluidity of the composites without sacrificing the mechanical performance, herein we demonstrated that one-dimensional hydroxyapatite (HAP) whiskers could be surface modified with 3-(trimethoxysilyl) propyl methacrylate, to decrease the viscosity of the resulting resins and to enhance the interfacial adhesion between the filler and matrix. Rheology results showed that the resin was still fluidic with loading of HAP whiskers up to 20 wt%, with Young's modulus increased by a factor of 98% and the ultimate tensile strength increased by 26%. Successful printing of the resin on a DLP printer was achieved with high resolution and fine surface, and the biocompatibility test showed an increase in cell viability with the addition of HAP whiskers. These results provide a promising approach to develop high-performance printable resin for orthopedic and related bioprinting.

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“…In their work, a simple, fast, and inexpensive step is introduced to fabricate polydimethylsiloxane microfluidic chips using enhanced internal scaffold removal. Tang et al 23 investigated the various 3D printing parameters on a transdermal drug delivery system with milliprojections printed using poly(lactic acid) (PLA). It was found that the smaller nozzle orifice and increased spacing between milliprojections produced better surface finish but had no significant effect on part accuracy.…”

Section: Introductionmentioning

confidence: 99%

Experimental investigation and statistical analysis of additively manufactured onyx‐carbon fiber reinforced composites

Piramanayagam

Mayandi

Rajini

et al. 2020

J of Applied Polymer Sci

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Availability of additive manufacturing has influenced the scientific community to improve on production and versatility of the components created with several associated technologies. Adding multiple substances through superimposing levels is considered as a part of three‐dimensional (3D) printing innovations to produce required products. These technologies are experiencing an increase in development nowadays. It requires frequently adding substance and has capacity to fabricate extremely complex geometrical shapes. However, the fundamental issues with this advancement include alteration of capacity to create special products with usefulness and properties at an economically viable price. In this study, significant procedural parameters: layer designs/ patterns (hexagonal, rectangular and triangular) and infill densities (30%, 40%, and 50%) were considered to investigate into their effects on mechanical behaviors off fused deposition modeling or 3D‐printed onyx‐carbon fiber reinforced composite specimens, using a high‐end 3D printing machine. Mechanical (tensile and impact) properties of the printed specimens were conclusively analyzed. From the results obtained, it was observed that better qualities were achieved with an increased infill density, and rectangular‐shaped design exhibited an optimum or maximum tensile strength and energy absorption rate, when compared with other counterparts. The measurable relapse conditions were viably evolved to anticipate the real mechanical qualities with an accuracy of 96.4%. In comparison with other patterns, this was more closely predicted in the rectangular design, using regression models. The modeled linear regression helps to define the association of two dependent variables linked with properties of the dissimilar composite material natures. The models can further predict response of the quantities before and also guide practical applications.

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Design and fabrication of transdermal drug delivery patch with milliprojections using material extrusion 3D printing

Cited by 26 publications

References 44 publications

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

Enhanced dispersion of hydroxyapatite whisker in orthopedics 3D printing resin with improved mechanical performance

Experimental investigation and statistical analysis of additively manufactured onyx‐carbon fiber reinforced composites

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