Design and fabrication of multifunctional temperature-sensitive magnetoliposomal nanostructures

Ghazanfari, Mohammad Reza; Jaafari, Mahmoud Reza; Shams, S. Fatemeh; Kashefi, Mehrdad

doi:10.1016/j.mtcomm.2017.09.005

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…Concerning the development of magnetoliposomes, common techniques include the ethanolic injection (EI) [15][16][17][18], thin film hydration (TFH) [19], reverse-phase evaporation (RPE) [10], and the double emulsion method (DE) [33]. The EI method has been demonstrated to be a simple, low cost and reproducible method for the fabrication of homogeneous AMLs, which consists in the injection of a lipid solution in ethanol to an aqueous solution of nanoparticles, above the melting temperature of the lipids and under vigorous agitation [34].…”

Section: Methods Of Magnetoliposomes Preparationmentioning

confidence: 99%

“…Posteriorly, the organic solvent is evaporated to form a gel phase and hydrated with a suitable buffer [10]. Nonetheless, it has been recently demonstrated, using the TFH method, that different parameters affect the loading efficiency of hydrophilic nanoparticles, such as the buffer type, concentration, pH, the liposome's composition, and components' stoichiometry [19]. For instance, formulations displayed in Table 1 demonstrate that the encapsulation efficiency is clearly influenced by the lipid composition of the liposome.…”

Section: Methods Of Magnetoliposomes Preparationmentioning

confidence: 99%

“…Currently, magnetoliposomes can be classified according to the distribution of nanoparticles in the liposome structure in four major classes: solid magnetoliposomes (SMLs), which either consist of a single particle coated by a lipid bilayer membrane [13,14], or a cluster of magnetic particles [15][16][17][18]; aqueous magnetoliposomes (AMLs), in which magnetic nanoparticles are dispersed in the inner aqueous lumen of liposomes [15][16][17][18][19][20]; nanoparticles embedded in the lipid bilayer membrane [21][22][23][24]; and nanoparticles bonded to the liposomes' surface [25][26][27].…”

Section: Types Of Magnetoliposomesmentioning

confidence: 99%

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Magnetoliposomes: recent advances in the field of controlled drug delivery

Veloso

Andrade

Castanheira

2021

Expert Opinion on Drug Delivery

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Magnetoliposomes have gained increasing attention as delivery systems, as they surpass many limitations associated with liposomes. The combination with magnetic nanoparticles provides a means for development of multimodal and multifunctional theranostic agents that enable on-demand drug release and real-time monitoring of therapy.Areas covered: Recently, several magnetoliposome structures have been reported to ensure efficient transport and delivery of therapeutics, while improving magnetic properties. Besides, novel techniques have been introduced to improve on-demand release, as well as to achieve sequential release of different therapeutic agents. This review presents the major types and methods of preparation of magnetoliposomes, and discusses recent strategies in the trigger of drug release, development of theranostic formulations, and delivery of drugs and biological entities.Expert opinion: Despite significant advances in efficient drug delivery, current literature lacks an assessment of formulations as theranostic agents and complementary techniques to optimize thermotherapy efficiency. Plasmonic magnetoliposomes are highly promising multimodal and multifunctional systems, providing the required design versatility to optimize theranostic capabilities. Further, photodynamic therapy and delivery of proteins/genes can be improved with a deeper research on the employed magnetic material and associated toxicity.A scale-up procedure is also lacking in recent research, which is limiting their translation to clinical use.

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Section: Methods Of Magnetoliposomes Preparationmentioning

confidence: 99%

Section: Methods Of Magnetoliposomes Preparationmentioning

confidence: 99%

Section: Types Of Magnetoliposomesmentioning

confidence: 99%

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Magnetoliposomes: recent advances in the field of controlled drug delivery

Veloso

Andrade

Castanheira

2021

Expert Opinion on Drug Delivery

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“…Additionally, a wide range of biomolecules and polymers could be performed as a matrix of magnetic-plasmonic structures, which were frequently investigated in reviews of polymeric coatings [157,158]. These structures are commonly used as nanocarriers for drug delivery [95,159].…”

Section: Structure Designmentioning

confidence: 99%

“…Currently, EPR is the most common delivery mechanism. It is confronted with some disadvantages, such as insufficient rate of drug delivery and release [159]. Heterodimer structures could be potentially used to overcome these inadequacies.…”

Section: Improved Performancesmentioning

confidence: 99%

Magnetic-Plasmonic Heterodimer Nanoparticles: Designing Contemporarily Features for Emerging Biomedical Diagnosis and Treatments

2019

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Magnetic-plasmonic heterodimer nanostructures synergistically present excellent magnetic and plasmonic characteristics in a unique platform as a multipurpose medium for recently invented biomedical applications, such as magnetic hyperthermia, photothermal therapy, drug delivery, bioimaging, and biosensing. In this review, we briefly outline the less-known aspects of heterodimers, including electronic composition, interfacial morphology, critical properties, and present concrete examples of recent progress in synthesis and applications. With a focus on emerging features and performance of heterodimers in biomedical applications, this review provides a comprehensive perspective of novel achievements and suggests a fruitful framework for future research.

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