Design and fabrication of microfluidics system integrated with temperature actuated microvalve

Zahra, Andleeb; Scipinotti, R.; Caputo, D.; Nascetti, A.; Cesare, G. de

doi:10.1016/j.sna.2015.10.050

Cited by 24 publications

(6 citation statements)

References 30 publications

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“…In addition to the purpose of the valve, we can categorize valves by the mechanism of actuation, which can be either active or passive. Active valves require an external energy source such as electrostatic [21][22][23], electromagnetic [24,25], pneumatic [26], hydraulic or photothermal [27][28][29]. These energy sources can control fluid flow through the deformation of a boundary, as in electromechanical [30] and pneumatic valves [31].…”

Section: Introductionmentioning

confidence: 99%

A Review of Capillary Pressure Control Valves in Microfluidics

Wang

Zhang

et al. 2021

Biosensors

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Microfluidics offer microenvironments for reagent delivery, handling, mixing, reaction, and detection, but often demand the affiliated equipment for liquid control for these functions. As a helpful tool, the capillary pressure control valve (CPCV) has become popular to avoid using affiliated equipment. Liquid can be handled in a controlled manner by using the bubble pressure effects. In this paper, we analyze and categorize the CPCVs via three determining parameters: surface tension, contact angle, and microchannel shape. Finally, a few application scenarios and impacts of CPCV are listed, which includes how CPVC simplify automation of microfluidic networks, work with other driving modes; make extensive use of microfluidics by open channel, and sampling and delivery with controlled manners. The authors hope this review will help the development and use of the CPCV in microfluidic fields in both research and industry.

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Section: Introductionmentioning

confidence: 99%

A Review of Capillary Pressure Control Valves in Microfluidics

Wang

Zhang

et al. 2021

Biosensors

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“…By contrast, active microvalves utilize an external energy source or system for actuating the mechanical and non-mechanical moving parts, thus generating large forces and faster response times [145]. The working principle of active mechanical microvalves involves coupling a thin deflectable membrane to microactuators with different mechanisms, including pneumatic, piezoelectric, electrostatic, magnetic, or thermal, while non-mechanical microvalves generally use smart materials, such as rheological or phase change materials [145][146][147][148]. Owing to their facile integration that allows for the precise control of fluids, the pneumatic actuation-based microvalves are the most commonly used ones.…”

Section: Microvalvesmentioning

confidence: 99%

Microelectromechanical Systems (MEMS) for Biomedical Applications

Chircov

Grumezescu

2022

Micromachines

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The significant advancements within the electronics miniaturization field have shifted the scientific interest towards a new class of precision devices, namely microelectromechanical systems (MEMS). Specifically, MEMS refers to microscaled precision devices generally produced through micromachining techniques that combine mechanical and electrical components for fulfilling tasks normally carried out by macroscopic systems. Although their presence is found throughout all the aspects of daily life, recent years have witnessed countless research works involving the application of MEMS within the biomedical field, especially in drug synthesis and delivery, microsurgery, microtherapy, diagnostics and prevention, artificial organs, genome synthesis and sequencing, and cell manipulation and characterization. Their tremendous potential resides in the advantages offered by their reduced size, including ease of integration, lightweight, low power consumption, high resonance frequency, the possibility of integration with electrical or electronic circuits, reduced fabrication costs due to high mass production, and high accuracy, sensitivity, and throughput. In this context, this paper aims to provide an overview of MEMS technology by describing the main materials and fabrication techniques for manufacturing purposes and their most common biomedical applications, which have evolved in the past years.

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“…Soft lithography, indeed, allows inexpensive rapid prototyping with low thermal budget. The microfluidics of the PCR-chip has been achieved by bonding together two PDMS layers [17]: the control layer that provides two thermoactuated valves and the flow layer that includes a serpentine-shaped channel for the DNA amplification, an inlet, and an outlet. Fabrication of the thermoactuated valves was achieved mixing the PDMS and the curing agent in the ratio 20:1 and placing the mixture in gentle vacuum at 600 mbar for 30min to remove the air bubbles.…”

Section: Loc Structure and Fabricationmentioning

confidence: 99%

“…Moreover, the same system could also be used for sensing the presence of pathogens through their DNA amplification, separation, and detection by hybridization with a complementary strand (possibly immobilized in the channel) and final recognition. The compactness and versatility of the device are achieved integrating on the same glass substrate thin-film metal heaters and amorphous silicon (a-Si:H) temperature sensors [17], [18] and coupling the so-obtained systemon-glass (SoG) to a specific polydimethylsiloxane (PDMS) microfluidic network [19]. This paper is organized as follows: Section II reports the details of the LoC structure and fabrication; Section III discusses the experimental results focusing on the DNA amplification through the PCR on chip and on the dsDNA separation through a microfluidic chip functionalized with streptavidin; finally, Section IV draws the conclusions.…”

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confidence: 99%

Integrated Sensor System for DNA Amplification and Separation Based on Thin Film Technology

Costantini

Petrucci

Lovecchio

et al. 2018

IEEE Trans. Compon., Packag. Manufact. Technol.

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This paper presents the development of a lab-onchip, based on thin-film sensors, suitable for DNA treatments. In particular, the system performs on-chip DNA amplification and separation of double-strand DNA into single-strand DNA, combining a polydimethylsiloxane microfluidic network, thin-film electronic devices, and surface chemistry. Both the analytical procedures rely on the integration on the same glass substrate of thinfilm metal heaters and amorphous silicon temperature sensors to achieve a uniform temperature distribution (within ±1°C) in the heated area and a precise temperature control (within ±0.5°C). The DNA separation also counts on the binding between biotinylated dsDNA and a layer of streptavidin immobilized into a microfluidic channel through polymer-brushes-based layer. This approach results in a fast and low reagents consumption system. The tested DNA treatments can be applied for carrying out the on-chip systematic evolution of ligands by exponential enrichment process, a chemistry technique for the selection of aptamers.Index Terms-Amorphous silicon sensor, lab-on-chip (LoC), systematic evolution of ligands by exponential enrichment (SELEX).

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Design and fabrication of microfluidics system integrated with temperature actuated microvalve

Cited by 24 publications

References 30 publications

A Review of Capillary Pressure Control Valves in Microfluidics

A Review of Capillary Pressure Control Valves in Microfluidics

Microelectromechanical Systems (MEMS) for Biomedical Applications

Integrated Sensor System for DNA Amplification and Separation Based on Thin Film Technology

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