Design and Fabrication of Magnetically Functionalized Core/Shell Microspheres for Smart Drug Delivery

Gong, Xiuqing; Peng, Suili; Wen, Weijia; Sheng, Ping; Li, Weihua

doi:10.1002/adfm.200801315

Cited by 114 publications

(88 citation statements)

References 40 publications

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“…Gong et al [79] created microcapsules of around 50 μm in size using a microfl uidic process, yielding shells comprised of IONPs embedded in a dextran layer surrounding a core loaded with aspirin. On application of an alternating magnetic fi eld, the shell was deformed, releasing the aspirin.…”

Section: Drug and Gene Deliverymentioning

confidence: 99%

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

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Iron-oxide nanoparticles (IONPs) represent a significant class of inorganic nanomaterial that is contributing to the current revolution in nanomedicine [1][2]. Their unique physical properties, including high surface area to volume ratios and superparamagnetism, confer useful attributes for medical applications such as magnetic resonance imaging (MRI), drug and gene delivery, tissue engineering and bioseparation [3].Two distinct classes of superparamagnetic IONP-based materials are currently used for medical applications: superparamagnetic iron-oxide (SPIO) nanoparticles with a mean particle diameter of 50-100 nm, and ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles with a size below 50 nm. Th ese two classes of IONPs have been studied widely for medical applications, particularly as the next (potential) generation of MRI contrast agents. Th ey are also seen as potential vectors for drug and gene delivery. Th e biodistribution of these nanoparticles can be altered by the application of an external magnetic fi eld; they also have potential applications in hyperthermia therapy as some magnetic particles can heat up under the infl uence of a localized high-frequency magnetic fi eld.Th e intent of this review is to present recent advances in the synthesis of IONPs and their subsequent stabilization in biological fluids using polymers, focusing on the current strategies used to graft polymers onto IONPs surfaces (see Figure 1) and the diff erent types of polymers used. Th e additional properties conferred by the polymers, such as targeting, eff ects on biodistribution and pharmacokinetics, are also discussed, and the main applications of IONPs are reviewed. Synthesis and properties of iron-oxide nanoparticlesSPIO and USPIO nanoparticles are the most extensively studied magnetic nanoparticles for biomedical applications as they are both biocompatible and easy to synthesize. Both are composed of ferrite nanocrystallites of magnetite (Fe 3 O 4 ) or maghemite (Fe 2 O 3 , γ). Over the last ten years, there has been an explosion of interest in these materials and this has been reflected in a large number of recent publications describing the synthesis and modifi cation of hybrid IONPs. In this review, we focus on the polymer modifi cation of the nanoparticles, and provide only minimal information on the inorganic synthesis of IONPs. For more detailed information on IONP synthesis, readers are referred to other reviews [3,4]. The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applicationsCyrille Boyer 1 * , Michael R. Whittaker 1 , Volga Bulmus 2 , Jingquan Liu 1 and Thomas P. Davis 1 * University of New South Wales, AustraliaOver the past decade, the synthesis of superparamagnetic nanoparticles, especially iron-oxide nanoparticles (IONPs), has been researched intensively for many high-technology applications, including enhanced storage media, biosensing and medical applications. In medicine, IONPs are used as contrast agents in magnetic resonance imaging and in hyperthermia...

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Section: Drug and Gene Deliverymentioning

confidence: 99%

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

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“…By using droplet microfluidics, several groups have prepared monodisperse BPM Tan and Takeuchi 2007;Dendukuri and Doyle 2009;Xu et al 2005Xu et al , 2009Oh et al 2008;Huang et al 2008;Yeh and Lin 2009;Hung et al 2010). Several monodisperse BPM of mixed drug have been successfully fabricated by droplet microfluidics, including poly(D, L-lactide-co-glycolide) (PLGA) (Xu et al 2009), alginate (Zhao et al 2009), chitosan (Gong et al 2009), and others Shum et al 2008;Nisisako et al 2006).…”

Section: Introductionmentioning

confidence: 98%

A modified microfluidic chip for fabrication of paclitaxel-loaded poly(l-lactic acid) microspheres

Liang

Zhang

et al. 2011

Microfluid Nanofluid

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In this article, we present a simple PDMS surface modification method based on poly(vinyl alcohol)/glycerol (PVA/Gly) solution immersion, self-assembled absorption, and heat treatment. The results of contact angle and ATR-FTIR demonstrate the superhydrophilic surface in modified PDMS. It can allow for the stable production of monodisperse droplet in a highly reproducible manner. In addition, we demonstrate the fabrication of monodisperse paclitaxel (PTX) loaded poly(L-lactic acid) (PLLA) microspheres on this kind of modification chip with solvent evaporation. The PLLA microspheres can be adjusted to a range of different sizes depending on the system flow rate. Determination of microsphere size is carried out by optical microscopy and image analysis to reveal less than 4% variation in microsphere size. Compared with the results of published papers, the presented data demonstrate that PTX-loaded PLLA microspheres show good physical properties (spherical and discrete), high-drug loading, encapsulation efficiency, a small initial burst, and sustained-release behavior due to outstanding monodispersity. With the characteristic to prepare high-quality, monodisperse, biodegradable microspheres, the versatile and simple microfluidic method facilitates the development of more reliable and reproducible drug delivery systems, which have great potential to benefit pharmaceutical and biological applications.

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“…It could also perform as a bioreactor for bacteria with long-term culture and monitoring [65]. In our previous work, we employed this method, together with polymerization processing and droplet encapsulation, for targeted delivery and release [66]. Another geometry-based generation method uses T-junction, by which two immiscible fluids are brought together.…”

Section: Droplet Generationmentioning

confidence: 98%

Manipulation of microfluidic droplets by electrorheological fluid

2009

Self Cite

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Microfluidics, especially droplet microfluidics, attracts more and more researchers from diverse fields, because it requires fewer materials and less time, produces less waste and has the potential of highly integrated and computer-controlled reaction processes for chemistry and biology. Electrorheological fluid, especially giant electrorheological fluid (GERF), which is considered as a kind of smart material, has been applied to the microfluidic systems to achieve active and precise control of fluid by electrical signal. In this review article, we will introduce recent results of microfluidic droplet manipulation, GERF and some pertinent achievements by introducing GERF into microfluidic system: digital generation, manipulation of "smart droplets" and droplet manipulation by GERF. Once it is combined with real-time detection, integrated chip with multiple functions can be realized.

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Design and Fabrication of Magnetically Functionalized Core/Shell Microspheres for Smart Drug Delivery

Cited by 114 publications

References 40 publications

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

A modified microfluidic chip for fabrication of paclitaxel-loaded poly(l-lactic acid) microspheres

Manipulation of microfluidic droplets by electrorheological fluid

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