Design and fabrication of gelatin-based hydrogel loaded with modified amniotic extracellular matrix for enhanced wound healing

Chen, Lifa; Ye, JueLan; Gao, Chong; Deng, Fei; Liu, Wei; Zhang, Qiang

doi:10.1016/j.heliyon.2023.e20521

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…These findings further elaborated the preference of the dAM-derived biomaterial compared to other prevalent biocompatible materials, such as GelMA, owing to its rich bioactive components ( Zhang et al, 2021 ). Chen et al (2023) have developed a composite hydrogel derived from a mixture of AdECMMA and GelMA for treating skin wounds. The wound healing process was improved accompanied by keratinization of the epidermal layer in the AdECMMA-GelMA group compared to the GelMA-only group.…”

Section: Biomedical Applications Of Am-derived Hydrogelsmentioning

confidence: 99%

“…The wound healing process was improved accompanied by keratinization of the epidermal layer in the AdECMMA-GelMA group compared to the GelMA-only group. Interestingly, the infiltration of inflammatory cells in the tissue treated with composite hydrogel was significantly less than that in the wounds treated with GelMAonly hydrogel, which is likely due to intrinsic anti-inflammatory characteristic of dAM matrix (Chen et al, 2023). Nasiry et al (2021) prepared three-dimensional (3D) microporous scaffolds by lyophilization of dAM hydrogels for the treatment of diabetic wounds.…”

Section: Tissue Engineering and Regenerationmentioning

confidence: 99%

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Amnion-derived hydrogels as a versatile platform for regenerative therapy: from lab to market

Kafili,

Niknejad,

Tamjid

et al. 2024

Front. Bioeng. Biotechnol.

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Section: Biomedical Applications Of Am-derived Hydrogelsmentioning

confidence: 99%

Section: Tissue Engineering and Regenerationmentioning

confidence: 99%

Amnion-derived hydrogels as a versatile platform for regenerative therapy: from lab to market

Kafili,

Niknejad,

Tamjid

et al. 2024

Front. Bioeng. Biotechnol.

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“…gallate [242], methacrylate grafted-decellularized human amniotic membrane/GelMA [243], platelet membrane camouflaged cerium NPs/GelMA [244], GS-loaded SA oxide and glycidyl-GelMA [245], GelMA/PVA incorporated with copper ion cross-linked TA NP [246], poly(N-isopropylacrylamide)/GelMA lower layer and alginate/polyacrylamide upper layer integrating various peptide-functionalized gold nanorods in both layers [247], GelMA hydrogel incorporated with EVs sourced from umbilical cord MSCs [248], Magnesium/Zinc-loaded GelMA [249] are some of the latest investigations displaying favorable outcomes in wound healing. Table 3 also represents recent studies where GelMA-based hydrogels revealed promising results in healing wounds.…”

Section: Application Of Gelma In Wound Healingmentioning

confidence: 99%

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Pramanik,

Alhomrani,

Alamri

et al. 2024

Biomed. Mater.

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Gelatin methacryloyl (GelMA) hydrogels have gained significant recognition as versatile biomaterials in the biomedical domain. GelMA hydrogels emulate vital characteristics of the innate extracellular matrix (ECM) by integrating cell-adhering and matrix metalloproteinase-responsive peptide motifs. These features enable cellular proliferation and spreading within GelMA-based hydrogel scaffolds. Moreover, GelMA displays flexibility in processing, as it experiences crosslinking when exposed to light irradiation, supporting the development of hydrogels with adjustable mechanical characteristics. The drug delivery landscape has been reshaped by GelMA hydrogels, offering a favorable platform for the controlled and sustained release of therapeutic actives. The tunable physicochemical characteristics of GelMA enable precise modulation of the kinetics of drug release, ensuring optimal therapeutic effectiveness. In tissue engineering, GelMA hydrogels perform an essential role in the design of the scaffold, providing a biomimetic environment conducive to cell adhesion, proliferation, and differentiation. Incorporating GelMA in three-dimensional printing further improves its applicability in drug delivery and developing complicated tissue constructs with spatial precision. Wound healing applications showcase GelMA hydrogels as bioactive dressings, fostering a conducive microenvironment for tissue regeneration. The inherent biocompatibility and tunable mechanical characteristics of GelMA provide its efficiency in the closure of wounds and tissue repair.GelMA hydrogels stand at the forefront of biomedical innovation, offering a versatile platform for addressing diverse challenges in drug delivery, tissue engineering, and wound healing. This review provides a comprehensive overview, fostering an in-depth understanding of GelMA hydrogel’s potential impact on progressing biomedical sciences.

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Challenges in Application: Gelation Strategies of DAT-Based Hydrogel Scaffolds

Li,

Liang,

et al. 2024

Tissue Engineering Part B: Reviews

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Design and fabrication of gelatin-based hydrogel loaded with modified amniotic extracellular matrix for enhanced wound healing

Cited by 3 publications

References 45 publications

Amnion-derived hydrogels as a versatile platform for regenerative therapy: from lab to market

Amnion-derived hydrogels as a versatile platform for regenerative therapy: from lab to market

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Challenges in Application: Gelation Strategies of DAT-Based Hydrogel Scaffolds

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