Design and experiments of a short-mixing-length baffled microreactor and its application to microfluidic synthesis of nanoparticles

Chung, Chen-Kuei; Shih, T. R.; Chang, Chia‐Chin; Lai, C. W.; Wu, B. H.

doi:10.1016/j.cej.2010.12.035

Cited by 66 publications

(27 citation statements)

References 27 publications

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“…Due to the great potential applications of microfluidic systems in intensification of liquid‐liquid mixing performance, the synthesis of organic materials by microfluidic techniques has been increased in biomedical and pharmaceutical engineering domains . Specifically, small dimensions of microfluidic devices confine the formation of vortices by restriction of the flow, so the solution in micro‐flow systems generates a laminar flow pattern .…”

Section: Introductionmentioning

confidence: 99%

On the mixing characteristics of a poorly water soluble drug through microfluidic‐assisted nanoprecipitation: Experimental and numerical study

et al. 2017

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Nanoprecipitation of curcumin from its ethanolic solutions was carried out at a microfluidic scale by the liquid anti‐solvent technique, in the presence of SDS as a stabilizer. Attention was mainly paid to the mixing angle of the water and ethanol in three micro‐fabricated channels. The nanosuspension quality was measured by particle size distribution and polydispersity index. BET surface area, dissolution test, FTIR spectra, and XRD patterns of the optimized nanosuspension were also evaluated experimentally. In particular, narrow size distribution of curcumin particles was achieved under well‐controlled conditions of large confluence angles. The amorphous ultrafine curcumin powder exhibited enhanced dissolution properties when compared to the raw material. To explain the precipitation results, a species 3D model was created by computational fluid dynamics (CFD). The pressure drop was compared to the quantitative experimental data to validate the CFD computations. Altogether, the similarities in observations and the mass fraction and velocity predictions of the 3D model revealed that the injection angle of microfluidic devices is a key parameter for the resultant curcumin nanoparticle size.

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Section: Introductionmentioning

confidence: 99%

On the mixing characteristics of a poorly water soluble drug through microfluidic‐assisted nanoprecipitation: Experimental and numerical study

et al. 2017

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“…For example, chaotic fluid flow in the herringbone microchannel is necessary for rare cells, such as circulating tumor cells, to increase the probability of coming in contact with antibodies, which are modified on the substrate's surface (Li et al 2013a;Stott et al 2010). Micromixers used in biological analysis, chemical synthesis, and clinical tests not only generate a miniaturized chemical reaction system and high integration but also reduce sample consumption (Atalay et al 2009;Chung et al 2011;Jiang et al 2004;Lee et al 2009;Liu et al 2008;Schönfeld and Hardt 2004). Microhybrid technology is widely used in rapid response (Nagaki et al 2005) and instability substance reactions (Wiles et al 2001) because of the quick and uniform mixing of materials and high heat transfer efficiency.…”

Section: Introductionmentioning

confidence: 99%

One-step electroplating 3D template with gradient height to enhance micromixing in microfluidic chips

Xiao

Zhang

et al. 2015

Microfluid Nanofluid

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“…Nevertheless, passive techniques are widely used in microfluidic systems as they are simpler to fabricate and easier to integrate into microfluidic systems. Examples of the wall modification technique include recessed grooves in the channel wall [6], herringbone-type walls [7], junction contraction [8], indentations and baffles [9,10], and periodic geometric features [11]. A combined method using both passive and active techniques was recently proposed by Chen et al [12] and Lim et al [13].…”

Section: Introductionmentioning

confidence: 99%

“…The T-shaped microchannel is widely used in microfluidic systems for various reasons. One is to improve mixing in microchannels as in this paper [9]. Another important application is the generation of droplets and/or bubbles in two-phase systems [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…For example, Fang et al [11] placed plane plates periodically in a mixing unit and showed a mixing improvement in a microchannel. Chung et al [9] implemented several mixing units consisting of several planar baffles, and showed that effective mixing could be obtained for a wide range of flow rate. We need to determine if an optimal configuration of repeated geometric features exists in terms of mixing enhancement and characterize the mixing performance in a microchannel.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Baffle Configuration on Mixing in a T-Shaped Micro-Channel

Kang

2015

Micromachines

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A numerical study was performed for a T-shaped microchannel to enhance mixing performance through a baffle configuration. The mixing performance was analyzed in terms of the DOM (degree of mixing) and the pressure load between the two inlets and outlet. Four different baffle configurations were designed and simulated to determine how they affect the mixing performance of a T-shaped microchannel. Among the four baffle configurations, a cyclic configuration of baffles produced the best results. It exhibited the fastest growth in the DOM along the microchannel. The cyclic configuration means that four baffles are attached to four side walls of the channel in a cyclic order. The mixing improvement occurs in two ways. One is in the baffle region, when the cyclic configuration causes the fluid flow to rotate in the cross section, unlike other configurations. The other improvement is observed in the remaining outlet branch after the baffle region. This improvement is due to twisting and elongation of the boundary between two fluids. The baffle size and the interval between two consecutive baffles are shown to be optimized in terms of the DOM for a given condition.

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Design and experiments of a short-mixing-length baffled microreactor and its application to microfluidic synthesis of nanoparticles

Cited by 66 publications

References 27 publications

On the mixing characteristics of a poorly water soluble drug through microfluidic‐assisted nanoprecipitation: Experimental and numerical study

On the mixing characteristics of a poorly water soluble drug through microfluidic‐assisted nanoprecipitation: Experimental and numerical study

One-step electroplating 3D template with gradient height to enhance micromixing in microfluidic chips

Effects of Baffle Configuration on Mixing in a T-Shaped Micro-Channel

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