Design and Experimental Analysis of a New Malleovestibulopexy Prosthesis Using a Finite Element Model of the Human Middle Ear

Valdezate, Luis Ángel Vallejo; Otamendi, Antonio Hidalgo; Hernández, Alberto; Lobo, Fernando; Sañudo, Elisa Gil-Carcedo; García, Luis Antonio Ribot

doi:10.1016/j.otoeng.2014.02.023

Cited by 6 publications

(2 citation statements)

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“…This type of prosthesis mimics the geometry of a human incus with the capability to attach to the heads of the malleus and stapes via two joint structures (identical to incudomalleolar and incudostapedial joints in geometry). Note that the incudal ligaments were removed in the prosthetic model, similar to numerical studies by (Milazzo et al 2020;Valdezate et al 2015) -for prosthesis design and optimization, they eliminated some components such as the incus, malleus, and/or their ligaments from their FE models to insert the prosthesis.…”

Section: Sound Transfer Function After Materials and Geometry Changes...mentioning

confidence: 99%

“…That is, it was rst aimed to analyze one altered parameter and keep others intact. According to the literature, several studies have been conducted to analyze material assignment to middle ear (columella-type) prostheses(Shende et al 2018;Yao et al 2013) and design more suitable implants(Milazzo et al 2020;Valdezate et al 2015). In contrast, in the present research, it was aimed to keep the shape of the incus intact, to which three distinct types of material were assigned.…”

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confidence: 96%

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Designing Precise Ossicular Chain Reconstruction with Finite Element Modelling

Mohseni-Dargah

Pastras

Mukherjee

et al. 2023

Preprint

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The disruption of the middle ear ossicles, specifically the incus, can occur due to various factors like infection, tumours, and trauma. This can lead to ossicular discontinuity, which causes conductive hearing loss (CHL). A commonly used therapeutic approach to address CHL is Ossicular Chain Reconstruction (OCR), which involves placing a prosthesis between the tympanic membrane (TM) and the stapes structure to restore hearing. However, current solutions for incus replacement in OCR have a high failure rate of around 40% within five years, mainly due to material biocompatibility, biomechanics, and prosthesis anchoring. To minimize extrusion and improve prosthesis stabilization, an implant customized to the patient's middle ear anatomy could utilise the protective effects and natural amplification of the native ossicular chain, while also eliminating direct contact with the malleus handle or TM. In this study, we developed and validated a novel Finite Element (FE) model for the middle ear to evaluate anatomically-modelled prosthetic incus, inspired by healthy incus geometry and made of different biomaterial candidates, including titanium, hydroxyapatite (HA), and tricalcium phosphate (TCP). The results of our biomechanical analyses indicate that the proposed FE model, which included the prosthetic incus, closely mimicked the normal middle ear vibration. This suggests that titanium, HA, and TCP may be useful materials for ossicular prostheses. Furthermore, our study highlights the potential of an anatomically modelled prosthetic incus as a promising option for OCR. This paper lays the foundation for designing personalized OCR using FE modelling, potentially leading to substantial improvements in hearing outcomes for patients.

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Section: Sound Transfer Function After Materials and Geometry Changes...mentioning

confidence: 99%

mentioning

confidence: 96%