Design and Evaluation of Ultradeformable Soft Elastic Nano Vesicle Ethosomes for Dermal Delivery

Samnani, Ajay; Shahwal, Vimal Kumar; Bhowmick, Mithun; Joshi, Amogh; Dubey, B. K.

doi:10.7439/ijbar.v3i2.232

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…The resulting shape resembles the shape of ethosomes from the previous study, unilamellar and spherical. 16 Particle Size Distribution, Polydispersity Index, and Zeta Potential…”

Section: Morphologymentioning

confidence: 99%

“…A sample of 1.0 g was applied to the skin surface. Then, at several time intervals (2,4,6,8,10,12,14,16,18,20, and 24 h) samples (3.0 mL) was taken from receptor compartment using a syringe and receptor compartment was refilled with the same amount of phosphate buffer pH 5.5. Next, the sample was inserted into the vial and its concentration measured by TLC-densitometry.…”

Section: In Vitro Penetration Testmentioning

confidence: 99%

“…16 The effects of ethanol and propylene glycol in the suspension as penetration enhancers will cause an interaction with the lipid molecules of the stratum corneum. It will increase the fluidity of the lipid bilayer.…”

mentioning

confidence: 99%

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Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Ramadon¹,

Wirarti²,

Anwar³

2017

JYP

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Background: One of the natural products that have many benefits is green tea (Camellia sinensis L.). It can be used to maintain health because of its high antioxidant activity from epigallocatechin gallate (EGCG). However, EGCG has a low ability to penetrate through the skin due to its hydrophilicity. The aim of this study is to improve the penetration of EGCG through the skin by lipid nanovesicle, namely ethosome. Methods: Ethosomes were made using thin layer hydration method. Ethosomes were formulated with different concentration, equal to 1% (F1), 1.5% (F2), and 2% (F3) of EGCG from green tea leaves extract. They were characterized, then a chosen formula would be formulated into a gel dosage form (ethosomal gel). A gel without ethosome (non-ethosomal gel) was prepared as a control. Both of them were evaluated their penetration enhancement ability using Franz diffusion cells with the abdomen skin of Sprague-Dawley rats. Results and Discussion: Based on the results, F1 had a spherical shape, Dv90 129.00 ± 0.00 nm, polydispersity index 0.05 ± 0.00, zeta potential at -62.6 ± 5.05 mV, and the highest entrapment efficiency of 54.39 ± 0.03 %.

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“…The resulting shape resembles the shape of ethosomes from the previous study, unilamellar and spherical. 16 Particle Size Distribution, Polydispersity Index, and Zeta Potential…”

Section: Morphologymentioning

confidence: 99%

Section: In Vitro Penetration Testmentioning

confidence: 99%

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Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Ramadon¹,

Wirarti²,

Anwar³

2017

JYP

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“…Ashitaba leaf phytoconstituents such as chalcone and coumarin act as antibacterial and anti-inflammatory, Increased penetration of ashitaba leaf nanoparticles in ethosomal gel occurs by various mechanisms. Nano ethosomal, which is smaller than 300 nm, can pass through the skin membrane to the deepest layers (Samnani et al, 2012). The ethanol and propylene glycol content in nano ethosomal increases transdermal penetration and causes drug interactions with stratum corneum lipid molecules (Zhou et al, 2018), this will increase the fluidity of the lipid bilayer and lead to an increase in stratum corneum permeability to drugs (Bendas and Tadros 2007).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Transdermal Delivery Nano Ethosomal Gel from Ashitaba Leaves on In-vivo Burn Wound Healing in Albino Rats

Al-Anshori,

Putri,

Ismi

et al. 2023

J. Med. Vet.

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This study aimed to evaluate the in-vivo burn wound healing process in albino rats treated using transdermal delivery nano ethosomal gel from ashitaba leaves. Ethosomal vesicles were formulated using soy lecithin, cholesterol, ethanol, water, and ashitaba leaf nanoparticles using the cold method. A total of 25 male rats were randomly divided into 5 groups, i.e., (C-) treated without nanoparticle extract, (C+) treated using 1% Silver Sulfadiazine®, treatment group treated nano ethosomal gel from ashitaba leaves with the respective doses were (T1) 1%, (T2) 2,5%, and (T3) 5%. Therapy was initiated on day 1 or after being induced by a burn wound for 14 days, twice a day. On the 15th day, a termination was carried out to take skin tissue from burn scars, then histopathology preparations were made with routine staining. Microscopic observations with an optical microscope on collagen, polymorphonuclear cell infiltration, angiogenesis, and re-epithelialization. The T3 group that was treated using 5% nano ethosomal gel showed the best burn wound healing, this may be caused by compounds in ashitaba leaf nanoparticles which have antioxidant, anti-inflammatory, and antibacterial effects, thus the use of transdermal delivery therapy of 5% ashitaba leaf nano ethosomal gel was effective for wound treatment burn on rat skin.

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“…Research on calcitonin showed evidence of this claim ( 16 ). For the treatment of cutaneous fungal infections, permeation of the selected drug into the deeper layers of the skin is necessary ( 17 ). The small size of the lipid nano particles improves the presence of nano particles in direct contact with stratum corneum and ensures entry of the encapsulated drugs into the skin ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

In-Vitro Activity of Nano Fluconazole and Conventional Flucon-azole against Clinically Important Dermatophytes

Bafrui¹,

Hazaveh²,

Bayat³

2020

ijph

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Background: Dermatophytosis is one of the most common fungal infections in humans. Antifungals such as fluconazole are effectively used for treating dermatophytosis; however, drug resistance was observed in many cases. Therefore, a newer treatment strategy is essential. Methods: This study (Conducted in the Laboratory of the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran in 2018) evaluated the antifungal susceptibility of nano fluconazole compared to conventional fluconazole on dermatophyte isolates using CLSI M38-A2guidelines. Dermatophyte species isolated from clinical cases of dermatophytosis were identified using PCR sequencing techniques. Zeta potential and size of the nano particles containing fluconazole were measured; scanning electron microscope (SEM) was used to determine nano particle structure. Results: The size of liposomal fluconazole obtained was 88.9 12.14 nm with –20.12 3.8 mV for zeta potential. The encapsulation rate for fluconazole was 75.1 4.2%. MIC50 for the three tested species was 32, 16, and 8 μg/ml for Trichophyton interdigitale, T. rubrum, and Epidermophyton floccosum isolates, respectively. The corresponding values for nano fluconazole were 8 μg/ml for the three tested species. Conclusion: MIC value for nano-fluconazole was lower than conventional fluconazole in all dermatophytes species tested; therefore, nano-fluconazole could inhibit the growth of dermatophytes better than fluconazole at a lower concentration of the drug.

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Design and Evaluation of Ultradeformable Soft Elastic Nano Vesicle Ethosomes for Dermal Delivery

Cited by 6 publications

References 11 publications

Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Efficacy of Transdermal Delivery Nano Ethosomal Gel from Ashitaba Leaves on In-vivo Burn Wound Healing in Albino Rats

In-Vitro Activity of Nano Fluconazole and Conventional Flucon-azole against Clinically Important Dermatophytes

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