Design and evaluation of split-ring resonators for aptamer-based biosensors

Abstract

Abstract. Split-ring resonators are electrical circuits, which enable highly sensitive readout of split capacity changes via a measurement of the shift in the resonance frequency. Thus, functionalization of the split allows the development of biosensors, where selective molecular binding causes a change in permittivity and therefore a change in split capacity. In this work, we present a novel approach using transmission line theory to describe the dependency between permittivity of the sample and resonance frequency. This theory allows the identification of all relevant parameters of a split-ring resonator and thus a target-oriented optimization process. Hereby all setup optimizations are verified with measurements. Subsequently, the split of a resonator is functionalized with aptamers and the sensor response is investigated. This preliminary experiment shows that introducing the target protein results in a shift in the resonance frequency caused by a permittivity change due to aptamer-mediated protein binding, which allows selective detection of the target protein.

Molecularly Imprinted Polymer Materials as Selective Recognition Sorbents for Explosives: A Review

“…New sampling methodologies (e.g., spraying micro-size organic droplets which are loaded with MIP nanoparticles into the gas samples [70]) could help to accelerate the selective and efficient extraction of targets from gas samples. In the future, new, sensitive, low-cost and disposable sensor substrates (e.g., split-ring resonators [71,72]) could be modified with nanoscale MIP materials, as nanolayers or nanoparticles, to create a commercial sensor for explosives.…”

P2.02 - Split-ring resonator: A new detector in liquid chromatography

“…The ring is like an RLC-resonator so the resonance frequency depends on the geometry of the ring and the relative permittivity in the split that acts as a capacitor. The resonance frequency of such circuit can be calculated via (1) [5,6]:…”

“…The half length of the resonator-ring is ݈ , ‫ݒ‬ is the propagation speed of the wave, ܼ is the impedance of the strip line, C is the resulting capacitance [5]. Obviously a higher permittivity leads to a lower resonance frequency ݂ ௦ .…”

Design and Investigation of Characteristic Structure Split Ring Resonator Circular of Microwave Metamaterial Absorber Parameter in X-band Frequency

“…Metamaterial absorber is an artificial composite structure which consists of two metal layers of the electric resonator, another side is a ground plane, and the middle is dielectric layer [5]. Split ring resonator is a structure represented electrical circuit about resonance frequency shifted [6] [7], and [8]. In this research, will explain a design and characteristic investigation of structure split ring resonator circular in microwave metamaterial absorber parameter, which means to know about the effect of wide radius characteristic in geometrical circular and also gap width of microwave metamaterial absorber parameter such as resonance frequency absorption rate.…”