Design and Evaluation of Polymeric Controlled Release Natamycin Ocular Inserts

Abstract

The main aim of this study is to develop ocular drug delivery system for Natamycin; a polyene antibiotic is highly useful for the treatment of conjunctivitis and keratitis. The ocuserts were prepared using different polymers such as eudragit L-100, eudragit S-100, eudragit RL-100, hydroxy propyl methyl cellulose phthalate and cellulose acetate phthalate at various proportion and combinations using PEG-400 as plasticizer. The prepared ocuserts were evaluated for their physicochemical parameters like drug content, weight uniformity, folding endurance, thickness, % moisture absorption and water vapour transmission rate. The in vitro drug release from the formulations was studied using commercial semi permeable membrane and the in vitro release kinetic datas were treated according to the diffusion models proposed by Higuchi and Peppas in order to access the mechanism of drug release from the formulations, which were following zero order kinetics. All the formulations showed no change in the physical appearance and the FTIR studies indicated no possibility of interaction between drug and polymer. The expected zero order release for one day was observed in the formulation D1 (3% Eudragit RL100 and 1% Eudragit L100)

Chick chorioallantoic membrane model forin ovoevaluation of timolol maleate–brimonidine tartrate ocular inserts

“…It responds to injury with an inflammatory process similar to what one would observe in the conjunctival tissue of a rabbit eye and chick embryo moments analog the nonstatic cornea. Normal CAM physiology and anatomy, in physical contact with the ocular insert for 48 h, supports us to claim that the developed formulation was biocompatible (Colombo et al, 1996;Rajasekaran et al, 2010). This suggests that the release of the drug from the device occurred in a controlled level without ''sudden leakage phenomenon'' and at a concentration below which there could be no inflammation and perhaps the folding endurance data supports up to certain extend that the ocular insert does not cause any physical friction to the nonstatic biological substrate.…”

“…The predominant mechanism of drug release from the formulations was determined by comparing their respective regression coefficients. Release exponent ''n'' was determined to know the drug transport mechanism (Ritger et al, 1987;Rajasekaran et al, 2010;Shivhare et al, 2012).…”

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“…[5][6][7][8][9][10] Having such a diverse range of effects, polymer films are an excellent substitute for most modern bandages, analogs of which are hard to find.…”

“…The standard technology is pouring on a surface. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Preparing gelling solution, the first stage of which is the dissolution stage precedes pouring. Depending on the properties of the ingredients, it is possible to dissolve hydrophilic polymers in water separately, heating it, and to dissolve active and auxiliary substances in matching solvents with further combining the formed solutions; or to dissolve auxiliary substances insolvent or a mixture of solvents, and then adding active pharmaceutical ingredients to this solution.…”

Contemporary Trends in Novel Ophthalmic Drug Delivery System: An Overview

“…The existing therapies are diminishing because of the development of new technologies. New drug delivery systems increase the amount and persistence of a drug in the vicinity of target cells and minimize the drug exposure of non target cells, in consequence promoting the therapeutic effects of a drug and reducing its toxic effects [1]. One of the most confronting routes of delivery for the pharmaceutical researchers is ophthalmic drug delivery [2].…”