Design and Evaluation of Ophthalmic Delivery Formulations

Soni, Vandana; Pandey, Vikas; Tiwari, Rahul; Asati, Saket; Tekade, Rakesh K.

doi:10.1016/b978-0-12-817909-3.00013-3

Cited by 28 publications

(22 citation statements)

References 164 publications

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“…In addition, neutral pH favours corneal uptake due to the high proportion of non‐ionized drug form. [ 23,24 ] Hence, the pH of the reconstituted VCZ SNEDDS was adjusted to 7.205 ± 0.006 with NaOH 0.1 m . Furthermore, it corresponds to the pH of VCZ stability.…”

Section: Resultsmentioning

confidence: 99%

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Self-nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in-vivo studies

Rasoanirina

Lassoued

Miladi

et al. 2020

Journal of Pharmacy and Pharmacology

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Objective This study investigates the effectiveness of self-nanoemulsifying drug delivery system (SNEDDS) in improving voriconazole transcorneal permeability. Methods Voriconazole-SNEDDS was prepared with isopropyl myristate, PEG 400, Tween 80 â and Span 80 â and was subjected for physicochemical characterization after reconstitution with NaCl 0.9% (1/9; v/v). In-vitro antifungal activity was assessed and compared with the marketed formulation. In-vivo studies, namely ocular irritation test via modified Draize test and pharmacokinetic study, were investigated using rabbit as animal model. Key findings Voriconazole-SNEDDS presented a droplet size of 21.353 AE 0.065 nm, a polydispersity index of 0.123 AE 0.003, a pH of 7.205 AE 0.006 and an osmolarity of 342.667 AE 2.517 mOsmol/l after reconstitution with NaCl 0.9%. Voriconazole-SNEDDS minimum inhibitory concentration (MIC 90 ) was similar to the one of marketed formulation for Candida species while it was significantly lower (P < 0.001) for Aspergillus fumigatus. Draize test revealed that Voriconazole-SNEDDS was safe for ocular administration. Voriconazole maximum concentration (5.577 AE 0.852 µg/ml) from SNEDDS was higher than marketed formulation (C max = 4.307 AE 0.623 µg/ml), and the T max was delayed to 2 h. The area under the concentration-time curve value of Voriconazole-SNEDDS was improved by 2.419-fold. Conclusion Our results suggest that SNEDDS is a promising carrier for voriconazole ocular delivery and this encourages further clinical studies.

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Section: Resultsmentioning

confidence: 99%

“…The osmolarity was 342.667 ± 2.517 mosm/l. Preparation is slightly hypertonic compared to that of tear fluid (310 mosmol/l) [ 24 ] but this is considered as safe for ocular administration. In fact, the human eye can tolerate hypertonic solutions better than hypotonic solutions.…”

Section: Resultsmentioning

confidence: 99%

Self-nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in-vivo studies

Rasoanirina

Lassoued

Miladi

et al. 2020

Journal of Pharmacy and Pharmacology

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“…The ciliary body forms a ring of muscular tissue around the interior part of the anterior sclera that extends from the posterior side of the iris to the beginning of the retina, where the ciliary margin zone (CMZ) is located (Figure 9) [199,200]. This structure has a triangular shape in its cross-section and it is linked to the lens via the zonules and to the vitreous internally [168,201,202]. The functions of the ciliary body include the production of aqueous humour and the regulation of both the intraocular pressure and the aqueous and blood flows.…”

Section: Ciliary Bodymentioning

confidence: 99%

Biofabrication of Artificial Stem Cell Niches in the Anterior Ocular Segment

et al. 2021

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The anterior segment of the eye is a complex set of structures that collectively act to maintain the integrity of the globe and direct light towards the posteriorly located retina. The eye is exposed to numerous physical and environmental insults such as infection, UV radiation, physical or chemical injuries. Loss of transparency to the cornea or lens (cataract) and dysfunctional regulation of intra ocular pressure (glaucoma) are leading causes of worldwide blindness. Whilst traditional therapeutic approaches can improve vision, their effect often fails to control the multiple pathological events that lead to long-term vision loss. Regenerative medicine approaches in the eye have already had success with ocular stem cell therapy and ex vivo production of cornea and conjunctival tissue for transplant recovering patients’ vision. However, advancements are required to increase the efficacy of these as well as develop other ocular cell therapies. One of the most important challenges that determines the success of regenerative approaches is the preservation of the stem cell properties during expansion culture in vitro. To achieve this, the environment must provide the physical, chemical and biological factors that ensure the maintenance of their undifferentiated state, as well as their proliferative capacity. This is likely to be accomplished by replicating the natural stem cell niche in vitro. Due to the complex nature of the cell microenvironment, the creation of such artificial niches requires the use of bioengineering techniques which can replicate the physico-chemical properties and the dynamic cell–extracellular matrix interactions that maintain the stem cell phenotype. This review discusses the progress made in the replication of stem cell niches from the anterior ocular segment by using bioengineering approaches and their therapeutic implications.

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“…This results in the need for frequent administration, leading to patient compliance issues. In addition, the additives in the formulation can lead to potential toxicity of the delicate ocular tissues [ 48 , 49 ]. A critical aspect is that the eye drops are only effective in treating anterior eye disease [ 50 ].…”

Section: Pharmaceutical Dosage Forms For Ocular Administrationmentioning

confidence: 99%

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

et al. 2021

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In ocular drug delivery, maintaining an efficient concentration of the drug in the target area for a sufficient period of time is a challenging task. There is a pressing need for the development of effective strategies for drug delivery to the eye using recent advances in material sciences and novel approaches to drug delivery. This review summarizes the important aspects of ocular drug delivery and the factors affecting drug absorption in the eye including encapsulating excipients (chitosan, hyaluronic acid, poloxamer, PLGA, PVCL-PVA-PEG, cetalkonium chloride, and gelatin) for modified drug delivery.

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Design and Evaluation of Ophthalmic Delivery Formulations

Cited by 28 publications

References 164 publications

Self-nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in-vivo studies

Self-nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in-vivo studies

Biofabrication of Artificial Stem Cell Niches in the Anterior Ocular Segment

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

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