Design and evaluation of ocular drug delivery system for controlled delivery of gatifloxacin sesquehydrate: In vitro and in vivo evaluation

Patel, Upendrakumar L; Chotai, Narendra P.; Nagda, Chirag D.

doi:10.3109/10837450.2010.502178

Cited by 20 publications

(21 citation statements)

References 12 publications

(25 reference statements)

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“…Several groups have investigated such systems, typically using degradable polymeric materials with various routes of administration, including topical drops or gels, 5,6 ocular insets, or contact lenses, 7,8 and subconjunctival or sub-Tenon injection . 9,10 Reformulated topical drops using mucoadhesive agents or gels tend to provide shorter windows of drug release, 11 which would necessitate additional instillation by the patient during the postoperative period.…”

Section: Introductionmentioning

confidence: 99%

Endophthalmitis Prophylaxis Using a Single Drop of Thermoresponsive Controlled-Release Microspheres Loaded with Moxifloxacin in a Rabbit Model

Mammen

Romanowski

Fedorchak

et al. 2016

Trans. Vis. Sci. Tech.

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PurposePostsurgical endophthalmitis is a sight-threatening problem. We introduce a simple approach by using a single application of thermoresponsive controlled-release microspheres, loaded with moxifloxacin, to prevent bacterial endophthalmitis in a rabbit endophthalmitis prevention model.MethodsWe separated 24 rabbits into 3 treatment groups in which topical drop treatment was placed onto the conjunctival cul-de-sac: (1) a single drop of controlled-release microspheres containing moxifloxacin, (2) a single drop of controlled-release microspheres without moxifloxacin, and (3) multiple topical treatment with moxifloxacin alone every 15 minutes for 1 hour. All rabbits were challenged, 1 hour after microspheres drop placement and immediately after the fifth topical dose of moxifloxacin, with anterior chamber injections of Staphylococcus aureus. Rabbits in the topical moxifloxacin group also were treated after challenge and four additional times over the next 24 hours. After 24 hours, the rabbits were clinically evaluated for endophthalmitis and the animals were euthanized to culture for intraocular S. aureus. The treatment groups were compared statistically for bacterial endophthalmitis.ResultsNo eyes had endophthalmitis, based on clinical presentation and/or positive culture, in the groups with controlled-release microspheres loaded with moxifloxacin (0/8, 0%) or multiple drops of topical moxifloxacin (0/8, 0%). In contrast, 8 of 8 eyes (100%; P = 0.0001), had endophthalmitis among eyes treated with controlled-release microspheres drops without moxifloxacin.ConclusionA single drop of controlled-release microspheres loaded with moxifloxacin was successful in preventing endophthalmitis. Further clinical studies will be required to confirm the full potential of controlled-release anti-infective loaded microspheres to prevent endophthalmitis.Translational RelevanceThis study presents a simple method of prophylaxis to prevent postsurgical endophthalmitis.

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Section: Introductionmentioning

confidence: 99%

Endophthalmitis Prophylaxis Using a Single Drop of Thermoresponsive Controlled-Release Microspheres Loaded with Moxifloxacin in a Rabbit Model

Mammen

Romanowski

Fedorchak

et al. 2016

Trans. Vis. Sci. Tech.

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“…3 carriers [17][18][19] , liposomes [20][21][22] or ocular implants 23,24 . These drug delivery systems have enabled an increase in the drug's residence time in the cornea and conjunctival sac, an increased ocular permeation and a prolonged drug release, resulting in less frequent administrations, irritation and both ocular and systemic side-effects.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Sustained drug release by contact lenses for glaucoma treatment—A review

Carvalho

Marques

Oliveira

et al. 2015

Journal of Controlled Release

124

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“…Five randomly selected ocular inserts were taken and weighed individually using calibrated digital balance. 13…”

Section: Weight Variation Testmentioning

confidence: 99%

Sustained Release Bioadhesive Ocular Inserts of Olopatadine Hydrochloride: Formulation and Characterization

Sabale¹,

Kumawat²,

Sabale³

2019

IJPER

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Objective: To develop bioadhesive ocular inserts of Olopatadine hydrochloride for treating the allergic eye conditions with sustained ocular delivery which will reduce dosing frequency. Methods: Matrix type ocular inserts were prepared by the solvent casting technique using teflon coated petri plates and characterized in vitro for drug release studies. Nine formulations were prepared having different ratios of polymers such as carbopol 980P, HPMC K4M and NaCMC (90:10, 70:30 and 50:50) and optimized. All the formulations were evaluated for thickness, weight variation, folding endurance, drug content uniformity, in vitro release study, bio/mucoadhesion studies, surface pH, swelling index, % moisture absorption, % moisture loss, release kinetics, histological study and stability study. Results: The optimized formulation 'F5' containing polymers Carbopol 980P and HPMC K4M in the ratio of 70:30 was selected on the basis of drug release studies. The formulation F5 was found to act as bio/mucoadhesive insert with sustained drug release by increasing residence time in the eye. Conclusion: The prepared inserts showed sustained drug release by increased residence time achieved through bioadhesion and thus may overcome the drawbacks of eye drops.

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Design and evaluation of ocular drug delivery system for controlled delivery of gatifloxacin sesquehydrate: In vitro and in vivo evaluation

Cited by 20 publications

References 12 publications

Endophthalmitis Prophylaxis Using a Single Drop of Thermoresponsive Controlled-Release Microspheres Loaded with Moxifloxacin in a Rabbit Model

Endophthalmitis Prophylaxis Using a Single Drop of Thermoresponsive Controlled-Release Microspheres Loaded with Moxifloxacin in a Rabbit Model

Sustained drug release by contact lenses for glaucoma treatment—A review

Sustained Release Bioadhesive Ocular Inserts of Olopatadine Hydrochloride: Formulation and Characterization

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