Design and evaluation of novel topical formulation with olive oil as natural functional active

Abstract

Currently, the innovative skin research is focused on the development of novel topical formulations loaded with natural functional actives. The health benefits of olive oil are unsurpassed and many others are revealed as research studies allow the understanding of its unlimited properties. Olive oil has a protective toning effect on skin, but it is not transported effectively into its layers. Aiming the development of a cosmetic formulation for skin photoprotection and hydration, we have prepared and characterized macro-sized particles, made of a hydrogel polymer, loaded with olive oil. Alginate beads were uniform in shape, with minimal oil leakage, offering interesting prospects for encapsulation of lipophilic and poorly stable molecules, like olive oil. In vitro photoprotection and in vivo tolerance tests were in favor of this application. Thus, this study suggests that the incorporation of the olive oil-loaded particles into a cream formulation provides strong moisturizing properties and a photoprotective potential, when applied to healthy subjects.

Lipophilic Metabolites and Anatomical Acclimatization of Cleome amblyocarpa in the Drought and Extra-Water Areas of the Arid Desert of UAE

“…The adapted mechanisms developed by C. amblyocarpa growing under drought conditions of UAE—in particular, the lipophilic metabolism—can be of importance to plant crops and farmers during drought conditions. Those lipophilic materials can provide crops growing in dry weather with an extra shield to protect them from water loss [59,60,61].…”

Formulation and development of a topical combination cream for arthritis management

“…apparent viscosity, spreadability, and extrudability were acceptable. Results from pre-formulation studies showed no incompatible materials in the formulations [19]. There were no allergic symptoms like skin irritation, erythema and edema, inflammation and redness up to 24 hr after 7 days of cream application on rat skin.…”

Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations

“…The total polyphenol content (TPC) was determined for the extract and extract-loaded NPs. It was estimated by using a modification of the Folin-Ciocalteu method [2]. In brief, a 100 µL aliquot of sample was added to 1 mL of Na 2 CO 3 (15%, w/v), and 2 mL of water.…”

“…Their applicability is vast, and is suitable in many areas of the pharmaceutical and cosmetic industries [1]. The literature suggests that natural products play an important role in photo-aging prevention (e.g., olive oil), topical application of antioxidants (e.g., vitamins C and E) in the protection of skin against UV-mediated damage [1,2], among many others.…”