Design and Evaluation of Mucoadhesive Buccal Patches of Venlafaxine

Asif, Hussain Mohammed; Rao, T. Rama; Ayesha, Nusrath; Anjum, Maimuna; Mohammed, Sharfuddin Waseem

doi:10.9734/bjpr/2015/12637

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…The different atenolol buccal patches has recorded the highest in vitro residence time of greater than 24 h with formulations FA-1 and FA-2 while the lowest in vitro residence time of 18.28±1.1 h with formulation FA-5 (table 4). In vitro residence time study demonstrates very good association of the prepared buccal patches with the buccal membrane for a sufficiently longer time period [50].…”

Section: In Vitro Residence Timementioning

confidence: 89%

Development Evaluation and Characterization of Buccal Patches Containing Atenolol Using Hydrophilic Polymers

ADHIKARI

PANDA²

2022

Int J App Pharm

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Objective: The present investigation focused on fabrication and evaluation of atenolol releasing buccal patches comprising mucoadhesive hydrophilic polymers like sodium alginate and tamarind seed polysaccharide with a drug-free backing layer (6 % ethylcellulose). Methods: Solvent evaporation technique being employed in the development of atenolol comprising buccal patches using mucoadhesive hydrophilic polymers. The prepared buccal patch formulations were tested for thickness, weight variation, folding endurance, drug content, moisture content, moisture absorption, % swelling, surface pH, in vitro residence time and mucoadhesion studies. The drug permeation through goat buccal mucosal membrane was conducted with the use of Franz diffusion cell in phosphate buffer saline, pH 6.8 and was subjected to FT-IR and SEM characterization. Stability study was performed as per ICH guidelines. Results: For all the buccal patch formulations, the average weight, thickness, drug content, moisture content, moisture absorption, % swelling, surface pH study exhibited satisfactory results. Out of 7 different buccal patches, the formulation FA-1 revealed the highest mucoadhesive strength (31.36±0.95 g), the force of adhesion (0.31±0.04 N), maximum swelling index (341±0.83 %) and more than 24 h in vitro residence time. The buccal patch formulation FA-1 indicated highest drug permeation (97.51 %) in 24 h and was found to be stable. FT-IR examination confirms lack of drug polymer interaction. SEM investigation reveals a smooth surface of the buccal patch. Conclusion: The developed buccal patches comprising atenolol can be very promising in increasing patient compliance and reducing dosing frequency.

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Section: In Vitro Residence Timementioning

confidence: 89%

Development Evaluation and Characterization of Buccal Patches Containing Atenolol Using Hydrophilic Polymers

ADHIKARI

PANDA²

2022

Int J App Pharm

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“…4. Folding endurance: Repetitive folding was done manually until the patch broke or folded up to 300 times, which is deemed acceptable for revealing excellent patch qualities (44). 5.…”

Section: Weight Uniformity/ Weight Variationmentioning

confidence: 99%

Buccal drug delivery system

Sharma

Verma

Khan

et al. 2022

ijhs

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It is well known that certain medications suffer hepatic first-pass metabolism or deteriorate in the digestive system, the buccal drug delivery method may be an alternative to oral administration. Because it is painless and may be swiftly and readily removed if the treatment must be terminated or interrupted, the buccal mucosa has long been ideal for administering medications. This paper focuses on the buccal drug delivery system had the goal of gathering recent literature and presenting a concise explanation of buccal patches by discussing the characteristics of an ideal mucoadhesive system, benefits of buccal delivery and disadvantages thereof, factors affecting buccal absorption, and various types of patches as well as the preparation method and composition thereof. The compilation of the data is also enhanced by adding market products as well as the patented, so that reader will get the complete knowledge about the buccal drug delivery.

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Formulation Development, Evaluation, and Optimization of Mucoadhesive Patches of Venlafaxine Hydrochloride for Buccal Delivery

Nilima¹,

Ashwini²

2021

Int J Pharma Bio Sci

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Design and Evaluation of Mucoadhesive Buccal Patches of Venlafaxine

Cited by 3 publications

References 9 publications

Development Evaluation and Characterization of Buccal Patches Containing Atenolol Using Hydrophilic Polymers

Development Evaluation and Characterization of Buccal Patches Containing Atenolol Using Hydrophilic Polymers

Buccal drug delivery system

Formulation Development, Evaluation, and Optimization of Mucoadhesive Patches of Venlafaxine Hydrochloride for Buccal Delivery

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