Design and evaluation of liposomal formulation of pilocarpine nitrate

Rathod, Sudha; Deshpande, S. G.

doi:10.4103/0250-474x.65014

Cited by 32 publications

(17 citation statements)

References 21 publications

(20 reference statements)

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“…mPEG 2000 -DSPE was incorporated for PEGylation which would further improve pharmacokinetic profile of formulation. The use of negatively charged lipid (DSPG) in optimized formulation is rationalized as it leads to improved entrapment efficiency by increasing the entrapped volume (Rathod & Deshpande, 2010). Various parameters like ammonium sulfate concentration, loading time, loading temperature, etc., were optimized to maximize drug loading in the liposomes.…”

Section: Preparation and Characterization Of Liposomesmentioning

confidence: 99%

Surface-modified Epirubicin-HCl liposomes and itsin vitroassessment in breast cancer cell-line: MCF-7

et al. 2015

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Section: Preparation and Characterization Of Liposomesmentioning

confidence: 99%

Surface-modified Epirubicin-HCl liposomes and itsin vitroassessment in breast cancer cell-line: MCF-7

et al. 2015

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“…Studies have shown that liposomes are also efficient carriers of amphiphilic drugs . Liposomes enhance the corneal permeability of lipophilic, hydrophilic as well as amphiphilic drugs due to their ability to come in close contact with cornea and conjunctiva Dharma et al, 1986) and increase the extent of corneal uptake by prolonging the corneal contact time (Rathod & Deshpande, 2010). Additionally, liposomes are completely biodegradable and relatively nontoxic.…”

Section: Conventional Liposomes: Modifications To Meet the Challengesmentioning

confidence: 99%

“…In general, charged liposomes resist aggregation and fusion better compared to uncharged liposomes and positively charged liposomes provide greater duration of action and higher drug delivery compared to negatively charged liposomes Weissmann et al, 1985;Rathod & Deshpande, 2010). This is because positively charged liposomes intimately interact with negatively charged cornea leading to prolonged residence time (Law et al, 2000).…”

Section: Surface Charge and Size Of Liposomesmentioning

confidence: 99%

Liposomes in topical ophthalmic drug delivery: an update

et al. 2014

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Topical route of administration is the most commonly used method for the treatment of ophthalmic diseases. However, presence of several layers of permeation barriers starting from the tear film till the inner layers of cornea make it difficult to achieve the therapeutic concentrations in the target tissue within the eye. In order to circumvent these barriers and to provide sustained and targeted drug delivery, tremendous advances have been made in developing efficient and safe drug delivery systems. Liposomes due to their unique structure prove to be extremely beneficial drug carriers as they can entrap both the hydrophilic and hydrophobic drugs. The conventional liposomes had several drawbacks particularly their tendency to aggregate, the instability and leakage of entrapped drug and susceptibility to phagocytosis. Due to this reason, for a long time, liposomes as drug delivery systems did not attract much attention of researchers and clinicians. However, over recent years development of new generation liposomes has opened up new approaches for targeted and sustained drug delivery using liposomes and has rejuvenated the interest of researchers in this field. In this review we present a summary of current literature to understand the anatomical and physiological limitation in achieving adequate ocular bioavailability of topically applied drugs and utility of liposomes in overcoming these limitations. The recent developments related to new generation liposomes are discussed.

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“…Liposomes as Vaccine Adjuvants: Liposomal vaccines can be made by associating microbes, soluble antigens, cytokines, or DNA with liposomes, the latter stimulating an immune response on expression of the antigenic protein 10 . Liposomes encapsulating antigens are subsequently encapsulated within alginate lysine microcapsules to control the antigen release and to improve the antibody response 11 .…”

Section: Applicationsmentioning

confidence: 99%

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2012

IJPSR

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The parenteral administration route is the most effective and common form of delivery for active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. Drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in terms of compliance, but also to improve the quality of the therapy and also may reduce the dosage frequency. Such reduction in frequency of drug dosing is achieved by the use of specific formulation technologies that guarantee the release of the active drug substance in a slow and predictable manner. The development of new injectable drug delivery system has received considerable attention over the past few years. A number of technological advances have been made in the area of parenteral drug delivery leading to the development of sophisticated systems that allow drug targeting and the sustained or controlled release of parenteral medicines.

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Design and evaluation of liposomal formulation of pilocarpine nitrate

Cited by 32 publications

References 21 publications

Surface-modified Epirubicin-HCl liposomes and itsin vitroassessment in breast cancer cell-line: MCF-7

Surface-modified Epirubicin-HCl liposomes and itsin vitroassessment in breast cancer cell-line: MCF-7

Liposomes in topical ophthalmic drug delivery: an update

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