Design and Evaluation of Linseed Mucilage Based Mucoadhesive Microspheres of Capacitabine: In Vitro Characterization

Abstract

Nanotechnology mediated drug delivery is being utilized nowadays for effective drug delivery at desired cell target. Many scientific investigators have utilized nanocarrier mediated drug delivery of antitumor drug for active targeting of encapsulated drug at desired target cells. Capacitabine is approved anticancer drug especially used for management of breast and colon cancer. Various conventional drug delivery systems of capacitabine are available for clinical use. However, limited oral bioavailability is major hurdle associated with conventional delivery of capacitabine. Thus, present study aimed to improve oral bioavailability of capacitabine through gastrorentive drug delivery approach. The capacitabine loaded mucilage-alginate microspheres were formulated using ionic gelation technique and characterized with respect to physicochemical characteristics. The drug loaded microspheres showed acceptable physicochemical characteristics. Thus, natural mucilage could be promising excipient for formulation of gastrorentive microspheres of capacitabine.