Design and Evaluation of Fast Dissolving Granules of Salbutamol Sulfate

Abstract

Objective: Appropriateness of administration and patient complaints are important factors in developing dosage forms, especially for children and elderly people. The goal of this research was to develop salbutamol sulfate granules that dissolve quickly to improve patient compliance. Methods: Five formulas (F1-F5) were prepared by wet granulation methods. Different type of excipients was used in the formulation like banana powder as super disinterring, mannitol, hydroxyl propyl methylcellulose; etc. The formulas were evaluated for flow properties, drug compatibility study by FTIR, drug content, and drug release profile. Results: The result revealed that the flowability of the five formulas has accepted flow properties; The FTIR studies of the formula F2 showed no drug-excipients interaction. All of the prepared formulas show an acceptable range of drug content, a rapid release of drug of about 95.2% within 10 min. These results indicate good and rapid release properties of salbutamol sulfate from fast dissolving granules. Conclusion: Salbutamol sulfate was successfully formulated as fast-dissolving granules by using banana powder.

Preparation of Salbutamol Sulphate Loaded Locust Bean Gum-Polyvinyl Alcohol Composite Cryogel for Drug Delivery

“…PVA has capability of cross linking with other cross-linking agents. Many polysaccharides have been combined with PVA to form composite cryogels that covers sodium alginate [35], chitosan [36], dextran [37] and carboxymethylcellulose [38]. Moreover, polymer blending of natural and synthetic polymers is considered more favourable as it is used to overcome the reduced biological performance of drug along with improvement in mechanical strength [39].…”