Design and Evaluation of Electrochemical Detectors for HPLC

Fleet, B.; Little, C.J.

doi:10.1093/chromsci/12.12.747

Cited by 187 publications

(39 citation statements)

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“…The wall-jet assembly and cell (Oxford Electrodes) have been described elsewhere [4,23]. A glassy carbon wall-jet disk electrode (area: 0.327cm2) plated with a mercury film was used for all experiments.…”

Section: Apparatus and Reagentsmentioning

confidence: 99%

Square wave adsorptive stripping voltammetry of nickel(II) in flowing systems at a wall‐jet mercury film electrode plated in situ

Rocha

Neto

Torres³

et al. 1997

Electroanalysis

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A rapid and highly sensitive adsorptive stripping voltammetry method for the measurement of traces of nickel(u) in flowing systems is described. The method involves a mass-transport controlled preconcentration step, during which the Niu-dimethylglyoxime complex is adsorbed onto an in situ plated mercury film wall-jet electrode, followed by a reductive square wave stripping scan. The optimization of the experimental conditions and square wave parameters was carried out in order to achieve high sensitivity, reproducibility and fast response. The detection limit, restricted by the amount of nickel in the blank solution, was found to be 1.3 x lo-'' M, with a relative standard deviation of 2 12.2 % (n = 15), for a 1-min accumulation time. Linear calibration plots were obtained up to 8 x lo-'' M. This method can be applied to continuous on-line monitoring of trace levels of nickel in flowing systems, enabling easy automation.

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Section: Apparatus and Reagentsmentioning

confidence: 99%

Square wave adsorptive stripping voltammetry of nickel(II) in flowing systems at a wall‐jet mercury film electrode plated in situ

Rocha

Neto

Torres³

et al. 1997

Electroanalysis

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“…(1973) and subsequently refined by Shoup and Kissinger (1978). Alternative designs are based on the "wall-jet principle" with the flowing stream from the LC column directed perpendicular to the working electrode surface (Fleet and Little, 1974). (b) Couiometric: These electrode systems attempt to oxidize 100% of the electroactive species and require a larger surface area than amperometric detectors.…”

Section: Electrochemical Detectionmentioning

confidence: 99%

Electrochemical Detection Methods for Monoamine Measurements in Vitro and in Vivo

Adams

Marsden

1982

Handbook of Psychopharmacology

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“…The stream or jet of this solution impinges perpendicularly onto the working electrode. Fleet and Little [17] reported on the advantages of the geometry. The cell design is reported less susceptible to fowling; presumably due to the cleansing action of the solution jet.…”

Section: Thin Layer Cell Amperometric Detectormentioning

confidence: 99%

Review: The Application of Liquid Chromatography Electrochemical Detection for the Determination of Drugs of Abuse

Honeychurch

2016

Separations

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This review (4 tables, 88 references) describes current developments in the design and application of liquid chromatography electrochemical detection (LC ED) based approaches for the determination of drugs of abuse. Specific emphasis is placed on operating details and performance characteristics for selected applications. LC ED has been shown to be highly sensitive and specific as well being a more economic option. A wide range of abused substances have been determined using this approach, including: cannabinoids, ethanol, opiates, morphine, mushroom toxins, benzodiazepines and several legal highs. Reverse-phase liquid chromatography with either amperometric or coulometric determination has been the most commonly reported applications. However, coulometric arrays have been also reported. Detection limits in the ng/mL region have been reported for most target analytes.

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Design and Evaluation of Electrochemical Detectors for HPLC

Cited by 187 publications

References 0 publications

Square wave adsorptive stripping voltammetry of nickel(II) in flowing systems at a wall‐jet mercury film electrode plated in situ

Square wave adsorptive stripping voltammetry of nickel(II) in flowing systems at a wall‐jet mercury film electrode plated in situ

Electrochemical Detection Methods for Monoamine Measurements in Vitro and in Vivo

Review: The Application of Liquid Chromatography Electrochemical Detection for the Determination of Drugs of Abuse

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