2018
DOI: 10.1016/j.xphs.2017.12.026
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Design and Evaluation of Bilayer Pump Tablet of Flurbiprofen Solid Dispersion for Zero-Order Controlled Delivery

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Cited by 15 publications
(6 citation statements)
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“…This biphasic release pattern is an important parameter responsible to extend the drug release. The SEM analysis of tablet dissolution showed that the significant porosity during the dissolution is the result of the leaching of water-soluble additives during dissolution [38]. The multiple parameters like weight gain (coating), agitation speed, orifice diameter, coating membrane thickness pH of media showed negligible effect on drug release [39][40][41][42][43][44].…”
Section: Discussionmentioning
confidence: 99%
“…This biphasic release pattern is an important parameter responsible to extend the drug release. The SEM analysis of tablet dissolution showed that the significant porosity during the dissolution is the result of the leaching of water-soluble additives during dissolution [38]. The multiple parameters like weight gain (coating), agitation speed, orifice diameter, coating membrane thickness pH of media showed negligible effect on drug release [39][40][41][42][43][44].…”
Section: Discussionmentioning
confidence: 99%
“…The heat exposure during the preparation and analysis of the eutectic mixtures was not expected to cause any drug degradation of the two rather stable compounds, in line with previous reports that employed hot melt extrusion. 22,23 The obtained molten mixture in the present work was then cooled to room temperature and kept in a desiccator before analysis. Characteristics and compositions for various drug−PEG eutectic systems are described in Table 1.…”
Section: ■ Materials and Methodsmentioning
confidence: 99%
“…The bilayer tablets were prepared by doublecompressing procedure with a lab tablet press (DP30A, Longli Tech, Beijing, China) (21,22). A fixed dose of the granules of IBU layer was loaded into the die cavity and precompressed manually, and then the powder of PE layer was filled and compressed to be a bilayer tablet.…”
Section: Preparation Of the Sustained Release Bilayer Tabletsmentioning
confidence: 99%