Design and evaluation of an air-insulated catheter for intra-arterial selective cooling infusion from numerical simulation and in vitro experiment

Jiang, Miaowen; Gao, Yuan; Yin, Zhichen; Ding, Yuchuan; Zheng, Yufeng; Zheng, Shiqiang; Wu, Chuanjie; Li, Ang; Fang, Jiancheng; Ji, Xunming

doi:10.1016/j.medengphy.2021.103736

Cited by 4 publications

(2 citation statements)

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“…Konstas demonstrated that the method including the in vitro study and a numerical theoretical model was an attempt to determine the feasibility of selective brain cooling with intracarotid saline infusion. 20 Our group also used this method to conduct a feasibility assessment on the intravascular interventional catheter 36 and heat exchanger 37 in the IA‐SCAI prototype system.…”

Section: Discussionmentioning

confidence: 99%

The intra‐arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy

Jiang

Gao

et al. 2022

CNS Neurosci Ther

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Section: Discussionmentioning

confidence: 99%

The intra‐arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy

Jiang

Gao

et al. 2022

CNS Neurosci Ther

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“…6 More importantly, NHPs are suitable for magnetic resonance imaging, endovascular procedures, long-term functional assessments, behavioral testing, and extensive physiological monitoring. 7,8 However, more efforts are still needed to optimize NHP stroke models in translational studies. For example, in the nerinetide pre-clinical evaluation, their NHP study did not use the approach of alteplase-based reperfusion, leading to a lack of detecting the potential effects of alteplase on nerinetide, which might account for the different effects of nerinetide in the stroke patients receiving alteplase or not in their phase III clinical trial.…”

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confidence: 99%

Improving Large Animal Ischemic Stroke Models for Translational Studies in the Era of Recanalization

Fisher

2023

Stroke

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Recanalization therapy with endovascular procedures has led to significant advances in the treatment of acute ischemic stroke. Animal models have been the basis for enhancing the development of novel treatments and therapeutic modalities. However, previous translational failures led to an increasing consensus that large animals should be included to bridge the gap between rodent and human studies. In the era of large vessel recanalization, large animal ischemic stroke models should be optimized for preclinical and translational stroke studies. Here we highlight recent progress of reproducing ischemic and reperfusion mechanisms in large animal models of stroke through surgical and endovascular methods. The importance of optimizing large animal stroke modeling is suggested by evaluating new findings from clinical trials and preclinical experiments using large animals, such as adopting advanced imaging analysis and long-term functional evaluation. Furthermore, we also acknowledge the importance of adhering to the Stroke Treatment and Academic Roundtable recommendations and the “3 R” principles to improve the quality and validity of large animal experiments. Large animal models offer many translational benefits; however, more work is still needed to enhance studies using large animal model on acute ischemic stroke in the era of recanalization.

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The blood heat exchanger in intra-arterial selective cooling infusion for acute ischemic stroke: A computational fluid-thermodynamics performance, experimental assessment and evaluation on the brain temperature

Jiang

Gao

et al. 2022

Computers in Biology and Medicine

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Design and evaluation of an air-insulated catheter for intra-arterial selective cooling infusion from numerical simulation and in vitro experiment

Cited by 4 publications

References 40 publications

The intra‐arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy

The intra‐arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy

Improving Large Animal Ischemic Stroke Models for Translational Studies in the Era of Recanalization

The blood heat exchanger in intra-arterial selective cooling infusion for acute ischemic stroke: A computational fluid-thermodynamics performance, experimental assessment and evaluation on the brain temperature

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