Design and Evaluation of an Oral Floating Matrix Tablet of Salbutamol Sulphate

Kumar, Shagalamarri Kiran; Sahu, RK; Sharma, Shalini; Sharma, SK; Jangde, Rajendra

doi:10.4314/tjpr.v11i4.7

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…A decrease in polymer : sodium bicarbonate ratio (2 : 1) contributed to the decrease in the floating lag time of HPMC K15M and HEC based formulations (F5 and F6, respectively). This is in agreement with previous studies, where higher amounts of the effervescent agent resulted in an increase in gas generation and hence faster floating [18,19].…”

Section: Discussionsupporting

confidence: 94%

Design and preparation of controlled floating gastroretentive delivery systems for enhanced fexofenadine hydrochloride oral bioavailability

Saab¹,

Samy²,

Issa³

et al. 2018

Trop. J. Pharm Res

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Purpose: To design and prepare effervescent floating gastroretentive tablets for controlled fexofenadine hydrochloride (HCl) release and enhanced oral bioavailability. Method: Various tablet formulations of the drug were prepared by direct compression. A systematic approach in the design of the formulations was adopted, where, first, formulations consisting of single polymers with a high polymer : sodium bicarbonate ratio were investigated for its physicochemical properties (in-vitro floating behaviour, drug release profile, etc). Next, improvement of tablets' properties was achieved by decreasing polymer : sodium bicarbonate ratio. Subsequently, a final optimization step involved blending polymers at different polymer : polymer ratios. The formulations were evaluated in vitro and in vivo in albino rabbits Results: The formulation consisting of hydroxypropyl methylcellulose K15M/hydroxypropyl methylcellulose K100LV at 1 : 2 ratio (F8) showed good floating properties (14 s floating lag time) with nearly zero order controlled drug release for 24 h (R 2 = 0.9876). In-vivo bioavailability studies of F8 in albino rabbits showed a significant increase in area under the curve (AUC, 134 %, p < 0.05) and hence an improvement in its oral bioavailability, compared to a commercial conventional product. Conclusion: The good quality of the effervescent floating gastroretentive tablets of fexofenadine HCl developed is an indication that the approach used is suitable for the formulation of the drug for controlled drug release and enhanced oral bioavailabiliy. This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest

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Section: Discussionsupporting

confidence: 94%

Design and preparation of controlled floating gastroretentive delivery systems for enhanced fexofenadine hydrochloride oral bioavailability

Saab¹,

Samy²,

Issa³

et al. 2018

Trop. J. Pharm Res

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show abstract

“…When in contact with gastric fl uid, sodium bicarbonate will liberate carbon dioxide gas (16,17). The gas entrapped within the matrix decreases the density of the tablet below 1 g cm -3 , providing buoyancy to the dosage form (16,18). While the system is fl oating in the gastric medium, the drug will be released slowly at a controlled rate without aff ecting the gastric emptying rate (7,19).…”

mentioning

confidence: 99%

“…When in contact with gastric fl uid, polymers will form a viscous matrix and retard the release of the drug from the system (16). When in contact with gastric fl uid, sodium bicarbonate will liberate carbon dioxide gas (16,17). The gas entrapped within the matrix decreases the density of the tablet below 1 g cm -3 , providing buoyancy to the dosage form (16,18).…”

mentioning

confidence: 99%