Design and Evaluation of a Dry Coated Drug Delivery System with Floating–Pulsatile Release

Zou, Hao; Xue-tao, Jiang; Kong, Lingshan; Gao, Shen

doi:10.1002/jps.21083

Cited by 24 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-Tensile strength of the coat polymer indicates its compressibility and compactibility for press coat formation. The tensile strength of HPMC was found to be 13.2 ± 0.8 kg cm -2 , thereby showing its practical applicability and good compressibility, which is in concordance with previous results (6).…”

Section: Drug-excipient Interaction Studysupporting

confidence: 91%

“…Therefore, there is need to design a delayed-onset extended-release (DOER) system of antihypertensive drugs so that their administration at bedtime would warrant drug release within the therapeutic level in the morning. Chronopharmaceuticals are synonymous with time-delayed-release dosage forms with the onset of release after a pre--programmed time interval (6).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers

2012

View full text Add to dashboard Cite

Several studies have demonstrated circadian rhythmicity for all body functions. Incidence of several cardiovascular events, like myocardial infarction, stroke and sudden cardiac death, also exhibit circadian rhythm (1, 2). These events are often observed early in the morning as the blood pressure (BP) rises significantly just before waking hours and declines to its lowest value around midnight (3). Lower concentrations of anti-hypertensive drugs during sleep are recommended because excessive reduction in blood pressure during sleep might predispose elderly hypertensive patients to ischaemic cerebrovascular disease (4). Conventional drug delivery systems seem inappropriate to address such medical needs by way of administering drugs, since there is a sharp rise in In view of the circadian rhythm of cardiovascular diseases, a delayed-onset extended-release (DOER) formulation of metoprolol tartrate (MT) was prepared. This was achieved through dissolution-guided optimization of the proportion of Methocel K4M and Methocel K15M. Core erosion ratio was greater than 50 %, thereby showing steady release of the drug after the lag time until complete dissolution. Optimized formulation produced a lag phase of 6 h followed by complete release of 98.7 ± 2.1 % in 24 h. Water uptake study revealed that Methocel K15M has lower water uptake (30 ± 1 %) than Methocel K4M (40 ± 2 %) after 24 h. Axial swelling of polymers was higher than swelling in the radial direction. Drug--polymer interaction study precludes any interaction between drug and polymer. Such a drug delivery system may provide a viable alternative for effective management of hypertension and other related disorders. This work also proposes an approach to attain DOER for a hydrophilic drug by using a hydrophilic swellable polymer in press coat.

show abstract

Section: Drug-excipient Interaction Studysupporting

confidence: 91%

mentioning

confidence: 99%

Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers

2012

View full text Add to dashboard Cite

show abstract

“…Floating pulsatile systems develop to overcome this drawback and have gained increasing interest during recent years for a number of drug therapies. In a study Zou et al (2008) developed a floating-pulsatile drug delivery system of verapamil HCL. The dry-coated tablet consists of a drugcontaining core coated with a hydrophilic erodible polymer followed by a buoyant layer, prepared with Methocel K4M, carbopol 934P, and sodium bicarbonate.…”

Section: Floating-pulsatile Systemsmentioning

confidence: 99%

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

et al. 2010

View full text Add to dashboard Cite

“…Zou et al [8] developed a floating pulsatile drug delivery (FPRT) system of Verapamil HCl using dry coating technique. The tablet consists of bilayer tablet in which one layer is buoyant layer and other layer is composed of dry coated tablet containing drug-containing core, coated by a hydrophilic polymer which is responsible for a lag phase in the onset of pulsatile drug release.…”

Section: Effervescent Floating Drug Delivery Systemsmentioning

confidence: 99%

Gastroretentive Drug Delivery Systems: From Conception to Commercial Success

Shah¹,

Prajapati²,

Patel³

2017

J Crit Rev

View full text Add to dashboard Cite

Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive technologies and some recently granted US patents in the field of GRDDS.

show abstract

Design and Evaluation of a Dry Coated Drug Delivery System with Floating–Pulsatile Release

Cited by 24 publications

References 37 publications

Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers

Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

Gastroretentive Drug Delivery Systems: From Conception to Commercial Success

Contact Info

Product

Resources

About