Design and evaluation of a biosynthesized cellulose drug releasing duraplasty

Stumpf, Taisa Regina; Sandarage, Ryan; Galuta, Ahmad; Fournier, Patrick; Li, Tongda; Kirkwood, Kathlyn M.; Yi, Xi-Nan; Tsai, Eve C.; Cao, Xudong

doi:10.1016/j.msec.2020.110677

Cited by 11 publications

(6 citation statements)

References 45 publications

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“…An in vitro study of neural stem cells cultured on a BC scaffold promotes their proliferation and differentiation by release growth factors from the BC scaffold. The in vivo study on mice indicated no inflammation reactions, which represent the duraplasty of BC scaffold for the treatment of spinal cord injuries [ 131 ].…”

Section: Applicationsmentioning

confidence: 99%

Bacterial Cellulose and Its Applications

Choi

Rao

et al. 2022

Polymers

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The sharp increase in the use of cellulose seems to be in increasing demand in wood; much more research related to sustainable or alternative materials is necessary as a lot of the arable land and natural resources use is unsustainable. In accordance, attention has focused on bacterial cellulose as a new functional material. It possesses a three-dimensional, gelatinous structure consisting of cellulose with mechanical and thermal properties. Moreover, while a plant-originated cellulose is composed of cellulose, hemi-cellulose, and lignin, bacterial cellulose attributable to the composition of a pure cellulose nanofiber mesh spun is not necessary in the elimination of other components. Moreover, due to its hydrophilic nature caused by binding water, consequently being a hydrogel as well as biocompatibility, it has only not only used in medical fields including artificial skin, cartilage, vessel, and wound dressing, but also in delivery; some products have even been commercialized. In addition, it is widely used in various technologies including food, paper, textile, electronic and electrical applications, and is being considered as a highly versatile green material with tremendous potential. However, many efforts have been conducted for the evolution of novel and sophisticated materials with environmental affinity, which accompany the empowerment and enhancement of specific properties. In this review article, we summarized only industry and research status regarding BC and contemplated its potential in the use of BC.

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Section: Applicationsmentioning

confidence: 99%

Bacterial Cellulose and Its Applications

Choi

Rao

et al. 2022

Polymers

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“…It comprises semi-ordered structures called microfibrils ( Figure 6 A). Cellulose microfibrils naturally occur in microbial biofilms [ 118 , 119 , 120 ], marine animals (e.g., Halocynthia roretzi [ 121 ]), and algae (green, gray, red, and yellow-green [ 112 ]). Cellulose microfibrils support structural reinforcement in biomaterials.…”

Section: Principal Polysaccharides Used For Biomedical Materialsmentioning

confidence: 99%

“…Purified cellulose with a high crystalline microfibrillar structure is synthesized by bacteria (e.g., Komagataeibacter xylinus and Gluconacetobacter hansenii [ 112 , 118 ]. A dilute sodium hydroxide solution removes impurities, and after washing and drying steps, cellulose membranes are easily formed ( Figure 6 C) [ 118 ]. The advantage of this process is that purified or hydrated cellulose is created without complicated processes using harsh chemicals ( Figure 6 C).…”

Section: Principal Polysaccharides Used For Biomedical Materialsmentioning

confidence: 99%

“…Bacterial cellulose can be used to develop scaffolds and membranes for human fibroblast GF-2 (FGF2) delivery [ 112 , 118 , 131 , 310 ]. Microbial cellulose membranes quickly incorporated GFs in their structures, supporting controlled release over 10 days [ 118 ]. Microbial cellulose-based materials also provide a prolonged release of VEGF for two weeks [ 311 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…( B ) Adapted with permission from [ 123 , 124 ]; published by IntechOpen, 2015 and American Chemical Society, 2017, respectively. ( C ) Adapted with permission from Reference [ 118 ]; Published by Elsevier, 2020. ( D ) Adapted with permission from References [ 125 , 126 , 127 ]; published by Elsevier, 2019 and 2020 and American Chemical Society, 2012, respectively.…”

Section: Figurementioning

confidence: 99%

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Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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Modified Bacterial Cellulose for Biomedical Applications

Tang

Heng

Chai

et al. 2022

Chemistry An Asian Journal

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Bacterial cellulose, or microbial cellulose, had gained tremendous interest as a hydrogel material for biomedical purposes in the recent years. It has many intrinsic physiological properties like fibrous nature, ultrafine 3D nanostructure network, high water holding capacity, excellent mechanical properties, biocompatibility and biodegradability that allow for the use of such purposes, and the lacking properties can be easily supplemented or enhanced by modifications. In this review, some of the biomedical applications that uses bacterial cellulose are discussed. These include wound healing, drug delivery, tissue engineering and tumor cell and cancer therapy. In each section, different modifications of BC are showcased and examined on how they benefit the application. Finally, key takeaways on these modifications are also deliberated.[a] K.

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Design and evaluation of a biosynthesized cellulose drug releasing duraplasty

Cited by 11 publications

References 45 publications

Bacterial Cellulose and Its Applications

Bacterial Cellulose and Its Applications

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

Modified Bacterial Cellulose for Biomedical Applications

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