Design and engineering of magneto-responsive devices for cancer theranostics: Nano to macro perspective

Soares, Paula I. P.; Romão, Joana; Matos, Ricardo; Silva, Jorge; Borges, João Paulo

doi:10.1016/j.pmatsci.2020.100742

Cited by 62 publications

(52 citation statements)

References 248 publications

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“…Even if, for the most common SPIONs employed in MRI, size distribution is about 20 nm, the huge specific surface of these nanoparticles thermodynamically induces aggregation into larger particle clusters, thus implying that surface stabilization is mostly required. Additionally, Fe-OH surface groups at the SPIONs surface are reactive groups that afford to oxidized heterogeneous clusters in air or acidic aqueous dispersion [ 103 ]. As a consequence, surface stabilization of these nanomaterials is a crucial step to obtain nanomaterials suitable for biomedical applications.…”

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

“…Superparamagnetism is the property of small ferromagnetic or ferrimagnetic particles of reversibly switching their average magnetization under the influence of an external magnetic field [ 103 ]. Typically, superparamagnetic nanoparticles have an anisotropic arrangement of their magnetic moments and tend to align them when exposed to a magnetic field (magnetization) in the direction of the field.…”

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

“…However, once the drug-loaded carrier is localized at the site of action, the drug should be released by peculiar stimuli of the tumor microenvironment such as enzymatic cleavage, pH, temperature or osmolarity changes. Magnetic targeting by superparamagnetic carriers not only significantly circumvents undesired side effects by addressing biodistribution to the target site, but also allows a dosage reduction while keeping the local concentration within the therapeutic window [ 103 , 110 ].…”

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

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Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

et al. 2021

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Cancer theranostics is a new concept of medical approach that attempts to combine in a unique nanoplatform diagnosis, monitoring and therapy so as to provide eradication of a solid tumor in a non-invasive fashion. There are many available solutions to tackle cancer using theranostic agents such as photothermal therapy (PTT) and photodynamic therapy (PDT) under the guidance of imaging techniques (e.g., magnetic resonance—MRI, photoacoustic—PA or computed tomography—CT imaging). Additionally, there are several potential theranostic nanoplatforms able to combine diagnosis and therapy at once, such as gold nanoparticles (GNPs), graphene oxide (GO), superparamagnetic iron oxide nanoparticles (SPIONs) and carbon nanodots (CDs). Currently, surface functionalization of these nanoplatforms is an extremely useful protocol for effectively tuning their structures, interface features and physicochemical properties. This approach is much more reliable and amenable to fine adjustment, reaching both physicochemical and regulatory requirements as a function of the specific field of application. Here, we summarize and compare the most promising metal- and carbon-based theranostic tools reported as potential candidates in precision cancer theranostics. We focused our review on the latest developments in surface functionalization strategies for these nanosystems, or hybrid nanocomposites consisting of their combination, and discuss their main characteristics and potential applications in precision cancer medicine.

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Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

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Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

et al. 2021

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“…Nanorods and particles with hexagonal shapes are the less common nanostructures used for drug delivery in cancer applications (Figure 1). A complete understanding of magnetic properties is essential for a proper implementation of nanoferrites in drug delivery applications [6]. The saturation magnetization (M s ), coercive force (H C ), and remanence (M R ) are the most popular magnetic parameters reported for nanoferrites to cancer drug delivery applications (Table A1).…”

Section: Figurementioning

confidence: 99%

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Osorio¹,

Herrera²,

Londoño³

et al. 2021

Ferrites - Synthesis and Applications

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Cancer is the second cause of death worldwide, whose treatment often involves chemotherapy. In a conventional therapy, drug is transported (and usually absorbed) across biological membranes through diffusion and systemic transport. The pathway that medicine must travel before reaching the desired location, can bring adverse or unwanted effects, which are mainly the result of: low bioavailability, low solubility and toxicity. To avoiding risks, nanoparticles coated with the drug could be used as a therapeutic substance to selectively reach an area of interest to act without affecting non-target cells, organs, or tissues (drug delivery). Here, the goal is to enhance the concentration of the chemotherapeutic drug in the disease parts of the body. Among all nanostructured systems, ferrites attract worldwide attention in drug delivery applications. It is due to their versatile magnetic and physicochemical properties. Here, it is reviewed and analyzed recent advances in synthesis, morphology, size, magnetic properties, functionalization with a focus in drug delivery applications of nanoferrites.

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“…Magnetic nanoparticles (NPs) are a class of inorganic materials widely used for biomedical applications in the last decades, namely for cancer theranostics applications [ 16 , 17 , 18 , 19 , 20 ]. The incorporation of magnetic nanoparticles into microgels gives rise to multi-responsive systems.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Dual-Stimuli Responsive Microgels in Nanofibrous Membranes for Cancer Treatment by Magnetic Hyperthermia

Gonçalves

Almeida

Borges

et al. 2021

Gels

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The delivery of multiple anti-cancer agents holds great promise for better treatments. The present work focuses on developing multifunctional materials for simultaneous and local combinatory treatment: Chemotherapy and hyperthermia. We first produced hybrid microgels (MG), synthesized by surfactant-free emulsion polymerization, consisting of Poly (N-isopropyl acrylamide) (PNIPAAm), chitosan (40 wt.%), and iron oxide nanoparticles (NPs) (5 wt.%) as the inorganic component. PNIPAAm MGs with a hydrodynamic diameter of about 1 μm (in their swollen state) were successfully synthesized. With the incorporation of chitosan and NPs in PNIPAAm MG, a decrease in MG diameter and swelling capacity was observed, without affecting their thermosensitivity. We then sought to produce biocompatible and mechanically robust membranes containing these dual-responsive MG. To achieve this, MG were incorporated in poly (vinyl pyrrolidone) (PVP) fibers through colloidal electrospinning. The presence of NPs in MG decreases the membrane swelling ratio from 10 to values between 6 and 7, and increases the material stiffness, raising its Young modulus from 20 to 35 MPa. Furthermore, magnetic hyperthermia assay shows that PVP-MG-NP composites perform better than any other formulation, with a temperature variation of about 1 °C. The present work demonstrates the potential of using multifunctional colloidal membranes for magnetic hyperthermia and may in the future be used as an alternative treatment for cancer.

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Design and engineering of magneto-responsive devices for cancer theranostics: Nano to macro perspective

Cited by 62 publications

References 248 publications

Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Incorporation of Dual-Stimuli Responsive Microgels in Nanofibrous Membranes for Cancer Treatment by Magnetic Hyperthermia

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