Design and engineering of 2D MXenes for point-of-care electrochemical detection of bioactive analytes and environmental pollutants

Mohanapriya, Devarasu; Satija, Jitendra; Senthilkumar, Sellappan; Kumar Ponnusamy, Vinoth; Thenmozhi, Kathavarayan

doi:10.1016/j.ccr.2024.215746

Cited by 10 publications

(3 citation statements)

References 205 publications

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“…where f0 represents the resonant frequency, Δm stands for the mass change, A is the active area (1.37 cm 2 ), ρ refers to the quartz density (2.648 g/cm 3 ), and μ represents the shear modulus of quartz (2.947 × 10 11 g/cm s 2 ). Thus, a deposited mass of 5.2 (±0.3) μg/cm 2 was obtained for PEDOT.…”

Section: Agnps-based Sensing Platformmentioning

confidence: 99%

“…The design of these analytical tools is oriented to the investigation of selective sensing materials that can be easily integrated within sensitive transducers based on electrochemical, optical, and mass change detection strategies. The electrochemical transducers provide easily measurable analytical signals that are straightforwardly related to the analyte concentration [2,3]. Further-more, the direct connection of the transducer with the sensing element can be easily achieved by using composite materials composed of conducting organic or inorganic components.…”

Section: Introductionmentioning

confidence: 99%

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MeNPs-PEDOT Composite-Based Detection Platforms for Epinephrine and Quercetin

Leau,

Marin,

Toader

et al. 2024

Biosensors

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The development of low-cost, sensitive, and simple analytical tools for biomolecule detection in health status monitoring is nowadays a growing research topic. Sensing platforms integrating nanocomposite materials as recognition elements in the monitoring of various biomolecules and biomarkers are addressing this challenging objective. Herein, we have developed electrochemical sensing platforms by means of a novel fabrication procedure for biomolecule detection. The platforms are based on commercially available low-cost conductive substrates like glassy carbon and/or screen-printed carbon electrodes selectively functionalized with nanocomposite materials composed of Ag and Au metallic nanoparticles and an organic polymer, poly(3,4-ethylenedioxythiophene). The novel fabrication method made use of alternating currents with controlled amplitude and frequency. The frequency of the applied alternating current was 100 mHz for the polymer deposition, while a frequency value of 50 mHz was used for the in situ electrodeposition of Ag and Au nanoparticles. The selected frequency values ensured the successful preparation of the composite materials. The use of readily available composite materials is intended to produce cost-effective analytical tools. The judicious modification of the organic conductive matrix by various metallic nanoparticles, such as Ag and Au, extends the potential applications of the sensing platform toward a range of biomolecules like quercetin and epinephrine, chosen as benchmark analytes for proof-of-concept antioxidant and neurotransmitter detection. The sensing platforms were tested successfully for quercetin and epinephrine determination on synthetic and real samples. Wide linear response ranges and low limit-of-detection values were obtained for epinephrine and quercetin detection.

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Section: Agnps-based Sensing Platformmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MeNPs-PEDOT Composite-Based Detection Platforms for Epinephrine and Quercetin

Leau,

Marin,

Toader

et al. 2024

Biosensors

View full text Add to dashboard Cite

show abstract

“…The presence of excessive H 2 O 2 in cells is known to cause damage to the central nervous system, resulting in detrimental diseases, including cancer. 12 Hence, selective and sensitive detection of H 2 O 2 is necessary to elevate quality of life.…”

Section: Introductionmentioning

confidence: 99%