Design and development of molecularly imprinted biodegradable polymers for nanomedicine

Gagliardi, Mariacristina

doi:10.1016/j.aiepr.2023.04.002

Cited by 3 publications

(3 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…based on MMIPs also offer new insights into pesticides [22], mycotoxins [22], antibiotics and drugs [18,20,22], protein [26], DNA and RNA [27], antibodies [22,26], and cancer biomarker [31] detection. Recently, MMIPs have begun to be used in various fields of biomedicine, such as disease diagnosis [31,32], pH and reducing stimuli-responsive drug and gene delivery [32][33][34][35], tumor imaging [33,34], and theranostics [33,34,36]. An alternative to the primary MIP synthesis by polymerization presented in Figure 1A may be a procedure involving off-the-shelf polymers (Figure 1B) [10,37].…”

Section: Introductionmentioning

confidence: 99%

“…Highly soluble in organic solvents, the polyamide polymer nylon can be re-precipitated and reformed easily, forming various types of porous structures [38,39,42,43], which in this work will be used for the first time for MMIPs synthesis. The introduction of ferrimagnetic magnetite nanoparticles (Fe 3 O 4 , MNPs) [33,34,36,44] into the nylon solution makes it possible to form MIPs on the surface of the nanoparticles, imparting magnetic properties to them. Nowadays, coated MNPs find vast applications in nanomedicine, magnetic separation, imaging, and theranostics [28,29,[45][46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of Magnetic Molecularly Imprinted Polymer for Methylene Blue Capture

Sedelnikova,

Poletaeva,

Golyshev

et al. 2023

Magnetochemistry

View full text Add to dashboard Cite

Hybrid magnetic molecularly imprinted polymers (MMIPs) have the advantages of the technology of molecularly imprinted material and magnetic nanoparticles. The magnetic properties of MMIPs allow easy magnetic separation of various pollutants and analytes. A convenient and simple approach has been developed for the preparation of MMIPs based on polyamide (nylon-6) and magnetic nanoparticles. The polymer matrix was formed during the transition of nylon-6 from a dissolved state to a solid state in the presence of template molecules and Fe3O4 nanoparticles in the initial solution. Methylene blue (MB) was used as a model imprinted template molecule. The MMIPs exhibited a maximum adsorption amount of MB reached 110 µmol/g. The selectivity coefficients toward MB structural analogs were estimated to be 6.1 ± 0.6 and 2.1 ± 0.3 for 15 μM hydroxyethylphenazine and toluidine blue, which shows high MMIP selectivity. To prove the MMIPs’ specificity in MB recognition, magnetic nonimprinted polymers (MNIPs) were synthesized without the presence of a template molecule. MMIPs exhibited much higher specificity in comparison to MNIPs. To show the remarkable reusability of the MMIP sorbent, more than four MB absorption and release cycles were carried out, demonstrating almost the same extraction capacity step by step. We believe that the proposed molecular imprinting technology, shown in the MB magnetic separation example, will bring new advances in the area of MMIPs for various applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of Magnetic Molecularly Imprinted Polymer for Methylene Blue Capture

Sedelnikova,

Poletaeva,

Golyshev

et al. 2023

Magnetochemistry

View full text Add to dashboard Cite

show abstract

“…In response to these challenges, MIES have emerged as a promising alternative for BPA detection. Molecular imprinting creates selective recognition sites in the polymer matrix that are complementary to the target analyte in size, shape, and chemical functionality [19][20][21][22]. This allows MIES to offer high selectivity towards BPA even in complex sample matrices [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

An Overview to Molecularly Imprinted Electrochemical Sensors for the Detection of Bisphenol A

Pan,

Wu,

Shi

et al. 2023

Sensors

View full text Add to dashboard Cite

Bisphenol A (BPA) is an industrial chemical used extensively in plastics and resins. However, its endocrine-disrupting properties pose risks to human health and the environment. Thus, accurate and rapid detection of BPA is crucial for exposure monitoring and risk mitigation. Molecularly imprinted electrochemical sensors (MIES) have emerged as a promising tool for BPA detection due to their high selectivity, sensitivity, affordability, and portability. This review provides a comprehensive overview of recent advances in MIES for BPA detection. We discuss the operating principles, fabrication strategies, materials, and methods used in MIES. Key findings show that MIES demonstrate detection limits comparable or superior to conventional methods like HPLC and GC-MS. Selectivity studies reveal excellent discrimination between BPA and structural analogs. Recent innovations in nanomaterials, novel monomers, and fabrication techniques have enhanced sensitivity, selectivity, and stability. However, limitations exist in reproducibility, selectivity, and stability. While challenges remain, MIES provide a low-cost portable detection method suitable for on-site BPA monitoring in diverse sectors. Further optimization of sensor fabrication and characterization will enable the immense potential of MIES for field-based BPA detection.

show abstract

Rapid and selective detection of tetracyclic antibiotics in environmental water using Cu2+-doped hydrophilic imprinted melamine resin

Gu,

Ding,

Zhang

et al. 2024

Microchemical Journal

View full text Add to dashboard Cite

Design and development of molecularly imprinted biodegradable polymers for nanomedicine

Cited by 3 publications

References 118 publications

Preparation of Magnetic Molecularly Imprinted Polymer for Methylene Blue Capture

Preparation of Magnetic Molecularly Imprinted Polymer for Methylene Blue Capture

An Overview to Molecularly Imprinted Electrochemical Sensors for the Detection of Bisphenol A

Rapid and selective detection of tetracyclic antibiotics in environmental water using Cu2+-doped hydrophilic imprinted melamine resin

Contact Info

Product

Resources

About