Design and Development of Ciprofloxacin Lipid Polymer Hybrid Nanoparticle by Response Surface Methodology

Jangde, Rajendra; Rabsanjani,; Khute, Sulekha

doi:10.5958/0974-360x.2020.00576.4

Cited by 8 publications

(2 citation statements)

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“…The buffered drug solution was added to the previously prepared lipid polymer (oil) phase. After that 20 mL of PVA (1.5% w/v) solution was used as an aqueous phase to play role of stabilizing agent in the preparation of lipid nanoparticles [26]. In the next step, under high-speed stirring, the lipid component was added dropwise to the aqueous phase over 24 h. The solvent-containing organic phase (DCM) was completely evaporated under continuous stirring at room temperature.…”

Section: Development Of Hesperidin Loaded Lipid-polymer Hybrid Nanopa...mentioning

confidence: 99%

Hesperidin-Loaded Lipid Polymer Hybrid Nanoparticles for Topical Delivery of Bioactive Drugs

et al. 2022

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Hesperidin is a bioflavonoid constituent that among many other biological activities shows significant wound healing properties. However, the bioavailability of hesperidin when applied topically is limited due to its low solubility and systemic absorption, so novel dosage forms are needed to improve its therapeutic efficacy. The objectives of this study were to develop hesperidin-loaded lipid-polymer hybrid nanoparticles (HLPHNs) to enhance the delivery of hesperidin to endogenous sites in the wound bed and promote the efficacy of hesperidin. HLPHNs were optimized by response surface methodology (RSM) using the Box-Behnken design. HLPHNs were prepared using an emulsion-solvent evaporation method based on a double emulsion of water-in-oil-in-water (w/o/w) followed by freeze-drying to obtain nanoparticles. The prepared formulations were characterized using various evaluation parameters. In addition, the antioxidant activity of HLPHN 4 was investigated in vitro using the DPPH model. Seventeen different HLPHNs were prepared and the HLPHN4 exhibited the best mean particle size distribution, zeta potential, drug release and entrapment efficiency. The values are 91.43 nm, +23 mV, 79.97% and 92.8%, respectively. Transmission electron microscope showed similar spherical morphology as HLPHN4. Differential scanning calorimetry verified the physical stability of the loaded drug in a hybrid system. In vitro release studies showed uniform release of the drug over 24 h. HLPHN4 showed potent antioxidant activity in vitro in the DPPH model. The results of this study suggest that HLPHNs can achieve sustained release of the drug at the wound site and exhibit potent in vitro antioxidant activity.

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Section: Development Of Hesperidin Loaded Lipid-polymer Hybrid Nanopa...mentioning

confidence: 99%

Hesperidin-Loaded Lipid Polymer Hybrid Nanoparticles for Topical Delivery of Bioactive Drugs

et al. 2022

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“…Ring of platinum was sterilized with flame then distilled water earlier each measurement [17].The accuracy of tensiometer was measuring surface tension and checked of pure aquatic i.e., 72.6 mNm -1 .The water intensity is taken from the average three- dimensional scale. The extreme power required to pull the ring on the optical connector is measured and associated with surface tension [18][19][20]. The results were found to be accurate within + 0.1 mNm -1 .…”

Section: Surface Tensionmeasurementsmentioning

confidence: 97%

The Effect of Temperature on the Critical Micelle Concentration and Micellar Solubilization of Poorly Water Soluble Drugs

Jangde

Chatterjee²,

Jain³

et al. 2022

Biosci., Biotech. Res. Asia

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Non-ionic surfactants, poly oxyethylene sorbitan adipose acid esters (polysorbate), were used in this work to explore the consequence of temperature on CMC throughout a wide temperature range. The phase separation model is used to analyze the enthalpy and entropy of micelle conformation. The Du Nöuys ring was used to determine the results' face pressure. The CMC standards were derived after the strong break down in surfactant attention plots of face pressure vs. logarithms. The CMC at continuous temperature decreases as the chain length of the surfactants rises, which is completely connected to the reduction in hydrophilicity of the motes. Because of the lower possibility of hydrogen bond conformation on high temperatures, the CMC of each surfactant initially declines and then increases as the system temperature rises. As the temperature rises, the commencement of micellization tends to happen at a faster rate. The focus of this research is on the characterization of solubilization of drugs that aren't sufficiently responsive. Face pressure measurements for nonionic surfactant TritonX-100 were also taken in order to assess the solubilization features. In the presence of colourful organic detergent, the medium's opposition and the likely positions of SMX and TMP were also discussed. TritonX-100, a nonionic surfactant, was also tested. In the presence of colourful organic detergents, the medium's opposition and the likely position of SMX and TMP were also discussed.

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Topical Delivery of Methoxsalen Co-loaded Curcumin Using Hybrid Nanocarrier-Based Polymeric Hydrogel for Synergistic Therapy in the Treatment of Psoriasis

Jamatia,

Das,

Das

2023

J Pharm Innov

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Design and Development of Ciprofloxacin Lipid Polymer Hybrid Nanoparticle by Response Surface Methodology

Cited by 8 publications

References 0 publications

Hesperidin-Loaded Lipid Polymer Hybrid Nanoparticles for Topical Delivery of Bioactive Drugs

Hesperidin-Loaded Lipid Polymer Hybrid Nanoparticles for Topical Delivery of Bioactive Drugs

The Effect of Temperature on the Critical Micelle Concentration and Micellar Solubilization of Poorly Water Soluble Drugs

Topical Delivery of Methoxsalen Co-loaded Curcumin Using Hybrid Nanocarrier-Based Polymeric Hydrogel for Synergistic Therapy in the Treatment of Psoriasis

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