Design and Development of Buccal Mucoadhesive Drug Delivery System for Perindopril = تصميم و تطوير نظام إيتاء دواء فموي لدواء بيريندوبريل

Abstract

The main objective of present study was to develop a buccal mucoadhesive drug delivery system for perindopril. Perindopril buccal mucoadhesive patches were developed by solvent casting technique using hydroxy propyl methylcellulose (HPMC), polycarbophil, sodium carboxymethylcellulose (SCMC) and sodium alginate as polymers for extended release of perindopril. Glycerine and DMSO were used as plasticizer and penetration enhancer respectively. Ethanol, methanol and dichloromethane were used as solvents. FTIR and DSC studies revealed no interaction between drug and polymers. The drug content in the perindopril patches was found to be uniform. The films exhibited good physical and mechanical properties. The surface pH of all the patches was within salivary pH range. Residual solvent content in patches are below the tolerated limits. The patches were found to have an extended release of the drug upto a period of 12 hours during ex vivo permeation studies with non-Fickian diffusion mechanism. The present study demonstrated the possibility of designing a buccal drug delivery system for perindopril.

Design of Controlled Release Mucoadhesive Buccal Tablets of Ivabradine HCL Using Sintering Technique

“…The above glass slide was allowed to move up and then down so that the buccal tablet was completely immersed in the disintegration medium at the lowest point and was out at the highest point. The time taken for complete erosion or detachment of the buccal tablet from the mucosal surface was recorded and repeated thrice [21,22].…”

“…The prepared buccal tablet was placed into the donor chamber of the diffusion cell and was wetted with 1 ml of phosphate buffer pH 6.8. The samples are withdrawn at a specific time interval from the sampling port and the same volume of fresh phosphate buffer pH 6.8 was replaced into the diffusion cell to maintain the sink condition [21,23]. To determine the amount of ivabradine permeated through the membrane, the samples are filtered, suitably diluted, and analyzed by UV spectrophotometer at 286 nm.…”