Design and development of a biocompatible montmorillonite PLGA nanocomposites to evaluate in vitro oral delivery of insulin

Lal, Seema; Perwez, Ahmad; Rizvi, Moshahid Alam; Datta, Monika

doi:10.1016/j.clay.2017.06.031

Cited by 28 publications

(13 citation statements)

References 54 publications

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“…Moreover, the MTT suggested that the MMT layers exhibited slightly better biocompatible properties than the MMT-Ag composite layers. These results are in good agreement with previous studies that reported MMT as being a non-toxic and bioinert material [53][54][55]. Moreover, Lal et al [55] concluded that their Mt-insulin-PLGA nanocomposites obtained using the double emulsion solvent evaporation method were highly biocompatible and did not show any toxicity against human embryonic kidney HEK-293.…”

Section: Resultssupporting

confidence: 91%

“…These results are in good agreement with previous studies that reported MMT as being a non-toxic and bioinert material [53][54][55]. Moreover, Lal et al [55] concluded that their Mt-insulin-PLGA nanocomposites obtained using the double emulsion solvent evaporation method were highly biocompatible and did not show any toxicity against human embryonic kidney HEK-293. Furthermore, Corrales et al [56] demonstrated in their study that PCL and PCL/MMT films are highly biocompatible.…”

Section: Resultssupporting

confidence: 91%

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Preparations of Silver/Montmorillonite Biocomposite Multilayers and Their Antifungal Activity

et al. 2019

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In this study, the results about the influence of the surface morphology of layers based on montmorillonite (MMT) and silver (Ag) on antimicrobial properties are reported. The coating depositions were performed in the plasma of a radio frequency (RF) magnetron sputtering discharge. The studied layers were single montmorillonite layers (MMT) and silver/montmorillonite multilayers (MMT-Ag) obtained by magnetron sputtering technique with a different surface thickness. The resultant MMT-Ag biocomposite multilayers exhibited a uniform distribution of constituent elements and enhanced antimicrobial properties against fungal biofilm development. Glow-discharge optical emission spectroscopy (GDOES) analysis revealed the formation of MMT-Ag biocomposite multilayers following the deposit of a silver layer for an MMT layer that was initially deposited on a Si substrate. The surface morphology and thickness evaluation of deposited biocomposite layers were performed by scanning electron microscopy (SEM). A qualitative analysis of the chemical composition of thin layers was performed and the elements O, Ag, Mg, Fe, Al, and Si were identified in the MMT-Ag biocomposite multilayers. The in vitro antifungal assay proved that the inhibitory effect against the growth of Candida albicans ATCC 101231 CFU was more emphasized in the case of MMT-Ag biocomposite multilayers that in the case of the MMT layer. Cytotoxicity studies performed on HeLa cells showed that the tested layers did not show significant toxicity at the time intervals during which the assay was performed. On the other hand, it was observed that the MMT layers exhibited slightly higher biocompatible properties than the MMT-Ag composite layers.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 91%

Preparations of Silver/Montmorillonite Biocomposite Multilayers and Their Antifungal Activity

et al. 2019

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“…Lal et al applied montmorillonite (Mt) as organic layer of emulsion, which is not only non-toxic and bio-inert itself, but also show excellent adsorption properties of toxins sourced from diet, bacteria, etc. [81] Optimal formulation processes high encapsulation efficiency and decreased burst release in more sustainable ways. Cell-penetrating peptides (R8, Tat and penetratin) and secretion peptide were studied by Zhu et al, and the resulting nanoparticles are proved to have greater permeability with the additional use of secretion peptide compared to penetratin alone [82] .…”

Section: Synthetic Polymeric Materialsmentioning

confidence: 99%

Developments in encapsulation of insulin: Is oral delivery now possible?

Pratap-Singh

Guo

Xie

et al. 2019

J Pharm Biopharm Res

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This review presents the possibilities of oral delivery of insulin. Insulin, being readily destroyed/transformed by the proteolytic enzymes and first-pass effects in the digestive system, has mainly been administered through injection, such as intravenous injection and transdermal injection. With developments in the material sciences, appropriate encapsulation methodologies have been developed that could be employed to protect insulin from the digestive effects of the human GI system, and thereby have opened a gateway of research exploring the oral route of insulin delivery. One approach is to incorporate insulin into an emulsion with an appropriate oil-phase, which protects the insulin from degradation. Coating with natural or synthetic polymeric materials, or with lipids, followed by size-reduction to 100-1000 nm is applied as another common approaches of insulin encapsulation. Other approaches like liposomes, nanogels, etc. are also being explored. This review gives a summary of methods of preparation as well as in vitro and in vivo bioavailability of insulin through these methods. It is observed that the oral bioavailability of insulin intake has increased from about 0.1% to about 20% for encapsulated insulin.

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“…Silicate based materials, especially clay minerals, are very oen utilized for this purpose. [1][2][3][4][5][6][7][8][9][10][11][12] Clay minerals belong to the group of layered silicates (phyllosilicates) where particular layers are composed of tetrahedral networks which contains mainly silicon in their central positions and octahedral networks containing mainly aluminum, magnesium or Fe(II) or Fe(III). Isomorphic substitution of the central cations takes place, which causes permanent negative charge on the layers.…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18][19] The modication can be done by transformation of the material on the monoionic form or intercalation of the various inorganic and organic molecules to the interlayer space can be performed as well. 14,15 These modied as well as original untreated materials can be utilized for the above mentioned targeted pharmaceuticals delivery or they can be used for the purpose of the continuous pharmaceutical release [1][2][3][4][5][6][7][8][9][10][11][12] or for the preparation of the antibacterial nanomaterials. 20,21 Biocompatibility of the newly invented materials can be a serious problem.…”

Section: Introductionmentioning

confidence: 99%