“…In addition to eOD-GT8, other germline-targeting immunogens are being developed, including a core gp120 derived from a clade C Env, 426c, which binds VRC01-class germline precursors and primes germline receptor-expressing B cells in vivo [30,34], and modified versions of the BG505 SOSIP.664 trimer, which can bind multiple bnAb germline specificities [35] (Figure 1B). Overall, these strategies aim to activate VRC01-like precursor B cell receptors (BCRs) with a germline-targeting immunogen, followed by boosting with more native-like Env molecules to shepherd Ab responses along favorable bnAb developmental pathways [29–33].…”