Design and characterization of ultrastable, biopassive and lubricious cyclic poly(2-alkyl-2-oxazoline) brushes

Yan, Wenqing; Divandari, Mohammad; Rosenboom, Jan‐Georg; Ramakrishna, Shivaprakash N.; Trachsel, Lucca; Spencer, Nicholas D.; Morgese, Giulia; Benetti, Edmondo M.

doi:10.1039/c7py02137b

Cited by 59 publications

(56 citation statements)

References 71 publications

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“…The improved non‐cell adhesive properties of the BOB could be attributed to molecular design: in a study on polyethyloxazoline brushes, which were grafted to a surface in either a loop or as linear grafts, it was shown that a loop can indeed be more efficient in resisting biofouling than linear chains . This finding can be attributed to the ability of hydrophilic loops to form significantly more hydrated brushes . The importance of hydration has previously also been shown for OEG‐based self‐assembled monolayers, where the protein repelling properties depend on the conformation of the OEG chains and the resulting hydration of the monolayer …”

Section: Antifouling Properties Of Electrospun Scaffoldsmentioning

confidence: 91%

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Ippel

Keizer

Dankers

2018

Adv Funct Materials

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The ultimate functionality of elastomeric materials can be largely influenced by the molecular design of antifouling additives that interact through directed hydrogen bonding bisurea motifs. Herein, three additives, composed of matching bisurea groups and antifouling oligo(ethylene glycol) (OEG) functionalities, are judiciously designed. The first additive is composed of one bisurea and one OEG, the second additive of one bisurea and two OEGs, and the third additive of two bisurea and one OEG. On solution-cast films, non-cell adhesive properties are dependent on the amount of incorporated OEG irrespective of the bisurea design; however, on 3D electrospun scaffolds only the additive that consists of two bisurea moieties connected via an OEG functionality ensures proper non-cell adhesive properties. Interestingly, robust non-cell adhesive properties are maintained, both with repeated cell seeding and after partial enzymatic degradation of the scaffold. These results highlight the importance of additive design in supramolecular functionalization and show that translation from simple 2D solution-cast films to 3D electrospun scaffolds is not trivial with respect to additive presentation and functionality.

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Section: Antifouling Properties Of Electrospun Scaffoldsmentioning

confidence: 91%

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Ippel

Keizer

Dankers

2018

Adv Funct Materials

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“…Recently, both linear and cyclic variants of poly(2‐oxazoline) were studied by Morgese et al . which also showed long‐term stability for poly(2‐oxazoline)s, both in terms of biopassivity to nonspecific adsorption and lubrication properties . On the contrary, Ulbricht et al .…”

Section: Introductionmentioning

confidence: 97%

Investigation of design parameters in generating antifouling and lubricating surfaces using hydrophilic polymer brushes

Pidhatika

Nalam

2019

J of Applied Polymer Sci

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Long-term stability of hydrophilic surface coatings that prevent fouling, cell adhesion and present a lubricious interface for biomaterials has been widely investigated in recent years. As an alternative to the gold standard poly(ethylene glycol) (PEG), poly(2-oxazoline)based coatings are promising due to their higher stability against oxidative degradation in comparison to PEG. In this study, we compare the antifouling and tribological properties of PEG and poly(2-methyl-2-oxazoline) (PMOXA) brush structures as a function of structural design parameters such as grafting density, chain length, and the monomer solubility. Brush properties such as hydration (number of H 2 O molecules per monomer), shear modulus, and serum adsorption as a function of design parameters were estimated using optical waveguide lightmode spectroscopy and quartz crystal microbalance/dissipation techniques. At high monomer surface densities, PMOXA showed approximately three times higher structurally associated H 2 O molecules per monomer in comparison to PEG brushes, leading to stiffer PMOXA brushes. We found that the chain stiffening of PMOXA brushes lead to higher macroscopic coefficients of friction; however presented similar adsorbed serum mass (high antifouling properties) when compared to PEG brushes.

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“…Nevertheless, the slope of the F f L profiles progressively decreased with the glass-transition temperature (T g ) of the polymer, which was 78, 16, and À 35°C for PMOXA, [64] PMOZI, [65] and PEG, [66] respectively, demon-…”

Section: Alternatives To Peg Brushesmentioning

confidence: 99%

Using Polymers to Impart Lubricity and Biopassivity to Surfaces: Are These Properties Linked?

Benetti

Spencer

2019

Helvetica Chimica Acta

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Polymer brushes have been widely applied for the reduction of both friction and non‐specific protein adsorption. In many (but not all) applications, such as contact lenses or medical devices, this combination of properties is highly desirable. Indeed, for many polymer‐brush systems, lubricity and resistance to biofouling appear to go hand in hand, with modifications of brush architecture, for example, leading to a similar degree of enhancement (or degradation) in both properties. In the case of poly(ethylene glycol) (PEG) brushes, this has been widely demonstrated. There are, however, examples where this behavior breaks down. In systems where linear brushes are covalently crosslinked during surface‐initiated polymerization (SIP), for example, the presence and the chemical nature of links between grafted chains might or might not influence biopassivity of the films, while it always causes an increment in friction. Furthermore, when the grafted‐chain topology is shifted from linear to cyclic, chemically identical brushes show a substantial improvement in lubrication, whereas their protein resistance remains unaltered. Architectural control of polymer brush films can provide another degree of freedom in the design of lubricious and biopassive coatings, leading to new combinations of surface properties and their independent modulation.

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Design and characterization of ultrastable, biopassive and lubricious cyclic poly(2-alkyl-2-oxazoline) brushes

Abstract: Bilayer films featuring cyclic, poly(2-alkyl-2-oxazoline) brush interfaces display excellent biopassivity, lubrication and long-term stability in chemically harsh aqueous environments.

Cited by 59 publications

References 71 publications

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Investigation of design parameters in generating antifouling and lubricating surfaces using hydrophilic polymer brushes

Using Polymers to Impart Lubricity and Biopassivity to Surfaces: Are These Properties Linked?

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