Design and characterization of poly (3-hydroxybutyrate-co-hydroxyhexanoate) nanoparticles and their grafting in whey protein-based nanocomposites

Corrado, Iolanda; Abdalrazeq, Manar; Pezzella, Cinzia; Girolamo, Rocco Di; Porta, Raffaele; Sannia, Giovanni; Giosafatto, C. Valeria L.

doi:10.1016/j.foodhyd.2020.106167

Cited by 17 publications

(16 citation statements)

References 40 publications

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“…Interestingly, a hybrid copolymer, such as PEG200-end capped PHBHHx, has been synthesized by A. hydrophila in microbial fermentation and the derived nanoparticle tested as intracellular delivery nanocarriers for sustained drug release (Lu et al, 2004 ). Noteworthy, besides drug delivery, incorporation of PHBHHx nanoparticle in whey protein-based films, improves the mechanical properties of the derived bio-plastics producing more extensible materials preserving their mechanical resistance (Corrado et al, 2021 ).…”

Section: In Vivo Strategies To Modulate Phb Properties: Syntmentioning

confidence: 99%

In vivo and Post-synthesis Strategies to Enhance the Properties of PHB-Based Materials: A Review

Turco

Santagata

Corrado

et al. 2021

Front. Bioeng. Biotechnol.

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The transition toward “green” alternatives to petroleum-based plastics is driven by the need for “drop-in” replacement materials able to combine characteristics of existing plastics with biodegradability and renewability features. Promising alternatives are the polyhydroxyalkanoates (PHAs), microbial biodegradable polyesters produced by a wide range of microorganisms as carbon, energy, and redox storage material, displaying properties very close to fossil-fuel-derived polyolefins. Among PHAs, polyhydroxybutyrate (PHB) is by far the most well-studied polymer. PHB is a thermoplastic polyester, with very narrow processability window, due to very low resistance to thermal degradation. Since the melting temperature of PHB is around 170–180°C, the processing temperature should be at least 180–190°C. The thermal degradation of PHB at these temperatures proceeds very quickly, causing a rapid decrease in its molecular weight. Moreover, due to its high crystallinity, PHB is stiff and brittle resulting in very poor mechanical properties with low extension at break, which limits its range of application. A further limit to the effective exploitation of these polymers is related to their production costs, which is mostly affected by the costs of the starting feedstocks. Since the first identification of PHB, researchers have faced these issues, and several strategies to improve the processability and reduce brittleness of this polymer have been developed. These approaches range from the in vivo synthesis of PHA copolymers, to the enhancement of post-synthesis PHB-based material performances, thus the addition of additives and plasticizers, acting on the crystallization process as well as on polymer glass transition temperature. In addition, reactive polymer blending with other bio-based polymers represents a versatile approach to modulate polymer properties while preserving its biodegradability. This review examines the state of the art of PHA processing, shedding light on the green and cost-effective tailored strategies aimed at modulating and optimizing polymer performances. Pioneering examples in this field will be examined, and prospects and challenges for their exploitation will be presented. Furthermore, since the establishment of a PHA-based industry passes through the designing of cost-competitive production processes, this review will inspect reported examples assessing this economic aspect, examining the most recent progresses toward process sustainability.

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Section: In Vivo Strategies To Modulate Phb Properties: Syntmentioning

confidence: 99%

In vivo and Post-synthesis Strategies to Enhance the Properties of PHB-Based Materials: A Review

Turco

Santagata

Corrado

et al. 2021

Front. Bioeng. Biotechnol.

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“…Polymer nanoparticles can also be conveniently prepared from preformed polymers [ 6 ]. Methods such as solvent evaporation [ 7 ], nanoprecipitation [ 8 , 9 ], salting-out [ 10 ], dialysis [ 11 ], supercritical fluid technology [ 12 ] and thermally induced phase separation [ 13 ], can be used for the preparation of polymer nanoparticles from preformed polymers.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Polyetherimide Nanoparticles by a Droplet Evaporation-Assisted Thermally Induced Phase-Separation Method

Zhu

Zhang

2021

Polymers

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The droplet evaporation effect on the preparation of polyetherimide (PEI) nanoparticles by thermally induced phase separation (TIPS) was studied. PEI nanoparticles were prepared in two routes. In route I, the droplet evaporation process was carried out after TIPS. In route II, the droplet evaporation and TIPS processes were carried out simultaneously. The surface tension and shape parameters of samples were measured via a drop shape analyzer. The Z-average particle diameter of PEI nanoparticles in the PEI/dimethyl sulfoxide solution (DMSO) suspension at different time points was tested by dynamic light scattering, the data from which was used to determine the TIPS time of the PEI/DMSO solution. The natural properties of the products from both routes were studied by optical microscope, scanning electron microscope and transmission electron microscope. The results show that PEI nanoparticles prepared from route II are much smaller and more uniform than that prepared from route I. Circulation flows in the droplet evaporation were indirectly proved to suppress the growth of particles. At 30 °C, PEI solid nanoparticles with 193 nm average particle size, good uniformity, good separation and good roundness were obtained. Route I is less sensitive to temperature than route II. Samples in route I were still the accumulations of micro and nanoparticles until 40 °C instead of 30 °C in route II, although the particle size distribution was not uniform. In addition, a film structure would appear instead of particles when the evaporation temperature exceeds a certain value in both routes. This work will contribute to the preparation of polymer nanoparticles with small and uniform particle size by TIPS process from preformed polymers.

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“…Amongst the biomaterial protein, edible films from various sources impressively expand environmental-friendly films due to their relative abundance and better film-forming capability [ 9 ]. Protein-based films are ideal for hydrophilic surfaces and provide oxygen and carbon dioxide barriers [ 10 , 11 ]. Structural specifications of protein-embedded edible films impart lots of functionalities such as intermolecular bonding [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Fenugreek Protein-Based Edible Film

Kumari

Punia

Petrů

et al. 2021

Foods

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The present investigation studied the physicochemical, mechanical, structural, thermal, and morphological attributes of a novel edible film formed from fenugreek protein concentrate. Films were produced at different pH—9, 10, 11, and 12—and the effect of the pH on the films was studied. As the pH increased, tensile strength increased while water vapor absorption decreased, which is interrelated to the surface morphological properties; as the pH increased, the surface became smoother and compact without any cavities. The films produced were darker in color. Fenugreek protein films exhibited good thermal stability. Fourier transform infrared spectroscopy (FTIR) revealed the presence of strong bonding for the films made at alkaline pH. X-ray diffraction analysis (XRD) indicated the major structure of the film was amorphous. The study demonstrated that the fenugreek protein concentrate film has influential characteristics and can be used as an edible packaging film.

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Design and characterization of poly (3-hydroxybutyrate-co-hydroxyhexanoate) nanoparticles and their grafting in whey protein-based nanocomposites

Cited by 17 publications

References 40 publications

In vivo and Post-synthesis Strategies to Enhance the Properties of PHB-Based Materials: A Review

In vivo and Post-synthesis Strategies to Enhance the Properties of PHB-Based Materials: A Review

Preparation of Polyetherimide Nanoparticles by a Droplet Evaporation-Assisted Thermally Induced Phase-Separation Method

Development and Characterization of Fenugreek Protein-Based Edible Film

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